68636-70-4Relevant articles and documents
Mannose-Decorated Multicomponent Supramolecular Polymers Trigger Effective Uptake into Antigen-Presenting Cells
Stra?burger, David,Stergiou, Natascha,Urschbach, Moritz,Yurugi, Hajime,Spitzer, Daniel,Schollmeyer, Dieter,Schmitt, Edgar,Besenius, Pol
, p. 912 - 916 (2018)
A modular route to prepare functional self-assembling dendritic peptide amphiphiles decorated with mannosides, to effectively target antigen-presenting cells, such as macrophages, is reported. The monomeric building blocks were equipped with tetra(ethylen
Targeting of phosphonoacetate to the liver: Synthesis of a phosphonoacetate-trilactoside conjugate
Bhat, Shridhar,Vaino, Andrew R.,Szarek, Walter A.
, p. 335 - 341 (2007/10/03)
As part of continuing studies on drug delivery to the human liver, a phosphonoacetate-trilactoside conjugate (12) has been synthesized in an overall yield of 23%. The shortness of the synthesis of this conjugate hinges upon a successful Michaelis-Arbuzov reaction of bromoacetamide 8 with tris-(trimethylsilyl) phosphite.