68668-89-3

Basic information

• Product Name: Benzeneacetyl chloride, 4-chloro-a-(4-chlorophenyl)-
• CAS NO: 68668-89-3
• Molecular Formula: C14H9Cl3O
• Molecular Weight: 299.584
• Mol File: 68668-89-3.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Benzeneacetyl chloride, 4-chloro-a-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetyl chloride, 4-chloro-a-(4-chlorophenyl)-(68668-89-3)
• EPA Substance Registry System: Benzeneacetyl chloride, 4-chloro-a-(4-chlorophenyl)-(68668-89-3)

Safety Data

• Hazardous Substances Data: 68668-89-3(Hazardous Substances Data)

Upstream product

• 108-90-7 chlorobenzene 
• 50-29-3 p,p'-DDT 
• 83-05-6 bis(4'-chlorophenyl)acetic acid 

Downstream Products

• 102545-60-8 6-[2,2-bis-(4-chloro-phenyl)-acetylamino]-benzo[1,3]dioxole-5-carboxylic acid methyl ester 
• 63168-17-2 bis-(4-chloro-phenyl)-acetic acid-(4-chloro-anilide) 
• 116605-08-4 7-amino-6-(4,4'-dichloro-benzhydryl)-7H-[1,3]dioxolo[4,5-g]quinazolin-8-one 
• 22731-54-0 2,2-bis(4-chlorophenyl)-N-(p-tolyl)ethen-1-imine 
• 1335439-51-4 10-chloro-7-(4-chlorophenyl)indolo[1,2-a]benzo[g]quinazoline 

Relevant articles and documents

Aerobic Electrochemical Transformations of DDT to Oxygen-Incorporated Products Catalyzed by a B12 Derivative

Electrochemical transformations of DDT into oxygen-incorporated products, amides and esters, catalyzed by a B12 derivative, heptamethyl cobyrinate perchlorate, have been developed under aerobic conditions. The dechlorinative oxygenation of DDT forms the acyl chloride as an intermediate for the synthesis of the amide and ester in the reaction with the amine and alcohol, respectively. This electrochemical method demonstrated with 20 oxygen-incorporated dechlorinated products up to 88% yields with 15 new compounds and was also successfully applied to the conversion of methoxychlor to an amide and ester.

Design, synthesis and in vitro activity of 1,4-disubstituted piperazines and piperidines as triple reuptake inhibitors

Monoamine transporters regulate the concentration of monoamine neurotransmitters, which are essential for vital physiological processes, and their dysfunction can cause several central nervous system diseases. Monoamine transporters currently appear to be the potential target in the management of these disorders. In this study, homologation and bioisosterism techniques have been used in the designing of new 1,4-disubstituted piperazines and piperidines. These derivatives were synthesized and evaluated as potential triple reuptake inhibitors for studying the structure-activity relationships. The most advanced compound, 1-(4-(5-benzhydryl-1H-tetrazol-1-yl)butyl)-4-(3-phenylpropyl)piperazine (2i), was able to inhibit monoamine neurotransmitter reuptake in an in vitro test (IC50?=?158.7?nM for 5-HT, 99?nM for NE and 97.5?nM for DA). These novel potent triple reuptake inhibitor-based 1,4-disubstituted piperazine and piperidine scaffolds deserve further systematic optimization and pharmacological evaluation.

Rh-Catalyzed annulations of: N -methoxybenzamides with ketenimines: Synthesis of 3-aminoisoindolinones and 3-diarylmethyleneisoindolinones with strong aggregation induced emission properties

Rhodium-catalyzed C-H activation/annulation reactions of ketenimines with N-methoxybenzamides furnished 3-aminoisoindolin-1-ones and 3-(diarylmethylene)isoindolin-1-ones. The synthesized 3-(diarylmethylene)isoindolin-1-ones exhibited aggregation induced emissions in aqueous tetrahydrofuran solution and strong green-yellow emissions in solids.