686721-46-0Relevant articles and documents
Design, synthesis and biological evaluation of novel 2-methoxyestradiol analogs as dual selective estrogen receptor modulators (SERMs) and antiangiogenic agents
Lao, Kejing,Wang, Yejun,Chen, Mingqi,Zhang, Jingjing,You, Qidong,Xiang, Hua
, p. 390 - 400 (2017/08/22)
2-methoxyestradiol is a novel agent showing both anti-angiogenic and vascular disrupting properties. In this study, a series of 11α-substituted 2-methoxyestradiol analogs have been designed and synthesized targeting dual ERα and microtubulin. Biological e
Chemical synthesis of six novel 17β-estradiol and estrone dimers and study of their formation catalyzed by human cytochrome P450 isoforms
Chen, Aaron Yun,Lee, Anthony J.,Jiang, Xiang-Rong,Bao, Ting Zhu
, p. 5372 - 5381 (2008/03/13)
Our earlier studies have shown that over 20 nonpolar 17β-estradiol metabolite peaks were detected following incubations of radioactive 17β-estradiol with human liver microsomes or recombinant human cytochrome P450 isoforms in the presence of NADPH as a co
