68726-28-3

Basic information

• Product Name: 2' 3'-DIDEOXYGUANOSINE 5'-TRIPHOSPHATE S
• Synonyms: 2’,3’-dideoxyguanosine-5’-o-triphosphate(ddgtp),sodiumsalt;2’,3’-dideoxyguanosine5’-triphosphate*sodium;2' 3'-DIDEOXYGUANOSINE 5'-TRIPHOSPHATE S;2'',3''-Dideoxyguanosine-5''-triphosphoric acid;2'',3''-DIDEOXYGUANOSINE 5''-TRIPHOSPHORIC ACID TRILITHIUM SALT (DDGTP);2′,3′-Dideoxyguanosine 5′-triphosphate sodium salt,ddGTP;2'3'-Dideoxyguanosine 5'-triphosphate sodiuM salt (ddTGTP);2',3'-dideoxy-GTP
• CAS NO: 68726-28-3
• Molecular Formula: C10H16N5O12P3
• Molecular Weight: 491.181
• Mol File: 68726-28-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 917.2°Cat760mmHg
• Flash Point: 508.5°C
• Appearance: /
• Density: 2.51g/cm³
• Storage Temp.: −20°C
• PKA: 0.97±0.50(Predicted)
• CAS DataBase Reference: 2' 3'-DIDEOXYGUANOSINE 5'-TRIPHOSPHATE S(CAS DataBase Reference)
• NIST Chemistry Reference: 2' 3'-DIDEOXYGUANOSINE 5'-TRIPHOSPHATE S(68726-28-3)
• EPA Substance Registry System: 2' 3'-DIDEOXYGUANOSINE 5'-TRIPHOSPHATE S(68726-28-3)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 68726-28-3(Hazardous Substances Data)

Usage

Uses

2`,3`-Dideoxy-guanosine 5`-(Tetrahydrogen Triphosphate) is used in the synthetic preparation of polymer tagged nucleotides for single molecule detection of SNPs polymorphisms by nanopore sequencing.

Downstream Products

• 38168-82-0 glyceric acid 1,3-biphosphate 

Relevant articles and documents

Anti-retroviral agents and delivery systems for the same

The present invention provides a method for preventing or treating disease caused by retroviruses, particularly human immunodeficiency virus. Liposomes are prepared containing phosphorylated derivatives of nucle-osides which act as chain-terminators of viral DNA. The phosphorylated nucleosides perse, without encapsulation in liposomes, do not readily enter cells. However, they are found to be effective if encapsulated in liposomes because they remain in liposomes longer, they do not escape easily from cells, and they constitute the active form for incorporation in viral DNA chains. When administered to a host, the liposomes are taken up by endocytic and phagocytic cells, which are important reservoirs of HIV infection. If coated with an appro-priate ligand, such as an immunoglobulin molecule, lipo-somes containing the phosphorylated nucleosides can be directed to phagocytic cells, CD4-positive cells, or infected host cells.