68728-34-7

Basic information

• Product Name: 5-(benzyloxy)-2-phenyl-1,3-dioxane
• CAS NO: 68728-34-7
• Molecular Formula: C₁₇H₁₈O₃
• Molecular Weight: 270.323
• Mol File: 68728-34-7.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 398.3°C at 760 mmHg
• Flash Point: 135.2°C
• Density: 1.15g/cm³
• Vapor Pressure: 3.42E-06mmHg at 25°C
• Refractive Index: 1.58
• CAS DataBase Reference: 5-(benzyloxy)-2-phenyl-1,3-dioxane(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(benzyloxy)-2-phenyl-1,3-dioxane(68728-34-7)
• EPA Substance Registry System: 5-(benzyloxy)-2-phenyl-1,3-dioxane(68728-34-7)

Safety Data

• Hazardous Substances Data: 68728-34-7(Hazardous Substances Data)

Usage

Description

5-(benzyloxy)-2-phenyl-1,3-dioxane is a chemical compound with the molecular formula C16H16O3. It is an organic compound that belongs to the class of dioxane derivatives, which are cyclic organic compounds containing a 1,3-dioxane moiety. This specific compound contains a benzyl group and a phenyl group attached to the 2 and 3 positions of the dioxane ring, respectively.

Uses

Used in Organic Synthesis:
5-(benzyloxy)-2-phenyl-1,3-dioxane is used as a building block in organic synthesis for the creation of more complex compounds. Its unique chemical structure and properties make it a valuable component in the synthesis of various organic molecules.
Used in Pharmaceutical Research:
In Pharmaceutical Research, 5-(benzyloxy)-2-phenyl-1,3-dioxane is used as a building block for the development of new pharmaceutical drugs. Its unique chemical structure and properties contribute to the design and synthesis of novel drug candidates.
Used in Material Development:
5-(benzyloxy)-2-phenyl-1,3-dioxane has potential applications in the development of new materials due to its unique chemical structure and properties. It can be used as a component in the synthesis of advanced materials with specific properties for various applications.
Used in Drug Development:
In Drug Development, 5-(benzyloxy)-2-phenyl-1,3-dioxane is used as a building block for the creation of new pharmaceutical drugs. Its unique chemical structure and properties make it a promising candidate for the development of innovative drug molecules with potential therapeutic applications.

Upstream product

• 100-39-0 benzyl bromide 
• 1708-40-3 2-phenyl-[1,3]dioxan-5-ol 
• 100-44-7 benzyl chloride 
• 100-52-7 benzaldehyde 

Downstream Products

• 14690-00-7 2-O-benzylglycerol 
• 76163-48-9 2-O-benzyl-1,3-di-O-palmitoyl-rac-glycerol 
• 76163-43-4 2-O-benzyl-1,3-di-O-stearoyl-rac-glycerol 
• 20441-81-0 α--β-benzyl-glycerin 
• 20441-82-1 α,γ-Bis--β-benzyl-glycerin 
• 20441-83-2 Benzyl-(β,γ-distearoyl-glycerin)-(β-benzyl-γ-N-benzyloxycarbonyl-glycyl-glycerin)-phosphat 
• 47916-93-8 Octadecanoic acid 2-{[2-benzyloxy-3-(2-benzyloxycarbonylamino-acetoxy)-propoxy]-hydroxy-phosphoryloxy}-1-octadecanoyloxymethyl-ethyl ester 
• 927814-91-3 2-(benzyloxy)-1,3-bis[(diisopropoxyphosphoryl)methoxy]propane 
• 19945-19-8 2-(benzyloxy)propane-1,3-diyl bis(4-methylbenzenesulfonate) 
• 86629-66-5 5-(benzyloxy)-1,3-dioxan-2-one 
• 18678-94-9 2-benzyloxy-3-hexadecyloxy-1-propanol 
• 18678-98-3 Rac_. 1-O-Hexadecyl-2-O-benzylglycero-3-phosphocholin 
• 105543-67-7 2-O-Benzyl-glycerin-1-iodhydrin 
• 98561-90-1 3-hydroxy-2(S)-O-benzylglycerol p-methylbenzenesulfonate 

Relevant articles and documents

BIPOLAR TETRAETHER LIPIDS

Disclosed herein, inter alia, are compounds, compositions, and liposomes and methods of thereof.

Synthesis and evaluation of symmetric acyclic nucleoside bisphosphonates as inhibitors of the Plasmodium falciparum, Plasmodium vivax and human 6-oxopurine phosphoribosyltransferases and the antimalarial activity of their prodrugs

Two new series of symmetric acyclic nucleoside bisphosphonates (ANbPs) have been synthesised as potential inhibitors of the Plasmodium falciparum (Pf) and vivax (Pv) 6-oxopurine phosphoribosyltransferases. The structural variability between these symmetric ANbPs lies in the number of atoms in the two acyclic linkers connecting the N9 atom of the purine base to each of two phosphonate groups and the branching point of the acyclic moiety relative to the purine base, which occurs at either the alpha or beta positions. Within each series, six different 6-oxopurine bases have been attached. In general, the ANbPs with either guanine or hypoxanthine have lower Ki values than for those containing either the 8-bromo or 7-deaza 6-oxopurine bases. The lowest Ki values obtained for the two parasite enzymes were 0.1?μM (Pf) and 0.2?μM (Pv) for this series of compounds. Two phosphoramidate prodrugs of these inhibitors exhibited antimalarial activity against Pf in infected erythrocyte cell culture with IC50 values of 0.8 and 1.5?μM. These two compounds exhibited low cytotoxicity in human A549 cells having CC50 values of >300?μM resulting in an excellent selectivity index.

Effect of Headgroups on Small-Ion Permeability across Archaea-Inspired Tetraether Lipid Membranes

This paper examines the effects of four different polar headgroups on small-ion membrane permeability from liposomes comprised of Archaea-inspired glycerolmonoalkyl glycerol tetraether (GMGT) lipids. We found that the membrane-leakage rate across GMGT lipid membranes varied by a factor of ≤1.6 as a function of headgroup structure. However, the leakage rates of small ions across membranes comprised of commercial bilayer-forming 1-palmitoyl-2-oleoyl-sn-glycerol (PO) lipids varied by as much as 32-fold within the same series of headgroups. These results demonstrate that membrane leakage from GMGT lipids is less influenced by headgroup structure, making it possible to tailor the structure of the polar headgroups on GMGT lipids while retaining predictable leakage properties of membranes comprised of these tethered lipids. Extremophiles require robust membranes with low ion permeability to survive in harsh conditions. These Archaea organisms achieve low membrane permeability, in part, by generating lipids with unusual structural features such as tethering of their lipid tails. A systematic study probing the effect of polar headgroups in synthetic Archaea-inspired lipids showed little dependence of membrane leakage rates of small ions as a function of headgroup structure.