68742-13-2

Basic information

• Product Name: (2E)-3-(4,5-dimethoxy-2-nitrophenyl)-2-(4-methoxyphenyl)prop-2-enoic acid
• Synonyms: (2E)-3-(4,5-dimethoxy-2-nitrophenyl)-2-(4-methoxyphenyl)prop-2-enoic acid
• CAS NO: 68742-13-2
• Molecular Weight: 359.335
• Mol File: 68742-13-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (2E)-3-(4,5-dimethoxy-2-nitrophenyl)-2-(4-methoxyphenyl)prop-2-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-3-(4,5-dimethoxy-2-nitrophenyl)-2-(4-methoxyphenyl)prop-2-enoic acid(68742-13-2)
• EPA Substance Registry System: (2E)-3-(4,5-dimethoxy-2-nitrophenyl)-2-(4-methoxyphenyl)prop-2-enoic acid(68742-13-2)

Safety Data

• Hazardous Substances Data: 68742-13-2(Hazardous Substances Data)

Upstream product

• 104-01-8 4-Methoxyphenylacetic acid 
• 20357-25-9 6-nitroveratraldehyde 

Downstream Products

• 68742-17-6 (E)-2-(4-methoxyphenyl)-3-(2-amino-4,5-dimethoxyphenyl)cinnamic acid 
• 68742-15-4 6,7-dimethoxy-3-(4-methoxyphenyl)-quinolin-2(1H)-one 

Relevant articles and documents

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Synthesis and biological evaluation of tylophorine-derived dibenzoquinolines as orally active agents: Exploration of the role of tylophorine e ring on biological activity

A series of novel tylophorine-derived dibenzoquinolines has been synthesized and their biological activity evaluated. Three assays were conducted: inhibition of cancer cell proliferation, inhibition of TGEV replication for anticoronavirus activity, and su

Antitumor agents 251: Synthesis, cytotoxic evaluation, and structure-activity relationship studies of phenanthrene-based tylophorine derivatives (PBTs) as a new class of antitumor agents

Polar phenanthrene-based tylophorine derivatives (PBTs) were designed, synthesized and evaluated as potential antitumor agents. These compounds contain a core phenanthrene structure and can be synthesized efficiently in excellent yield. The newly synthesized PBTs were evaluated for cytotoxic activity against the A549 human cancer cell line. Among them, N-(2,3-methylenedioxy-6-methoxy-phenanthr-9-ylmethyl)-l-2-piperidinemethanol (34) and N-(2,3-methylenedioxy-6-methoxy-phenanthr-9-ylmethyl)-5-aminopentanol (28) showed the highest potency with IC50 values of 0.16 and 0.27 μM, respectively, which are comparable to those of currently used antitumor drugs. A structure-activity relationship (SAR) study was also explored to facilitate the further development of this new compound class.