68760-55-4Relevant articles and documents
Enantioselective total synthesis of (R)-strongylodiols A and B
Reber, Stefan,Kn?pfel, Thomas F.,Carreira, Erick M.
, p. 6813 - 6817 (2003)
We describe an expeditious enantioselective total synthesis of the acetylenic marine natural products (R)-strongylodiols A and B. Central to the strategy is the use of Zn(OTf)2, amine base, and N-methyl ephedrine to mediate the direct addition of a 1,3-diyne to two long-chain aliphatic aldehydes in useful selectivities and yields.
Asymmetric synthesis of cytotoxic sponge metabolites R-strongylodiols A and B
Kirkham, James E. D.,Courtney, Timothy D. L.,Lee, Victor,Baldwin, Jack E.
, p. 5645 - 5647 (2007/10/03)
The asymmetric synthesis of the marine sponge natural products, R-strongylodiols A 1 and B 2 using a minimum protection strategy is described. The chirality of the natural products was introduced via the Noyori asymmetric reduction of ynones.
