687636-93-7

Basic information

• Product Name: 2-BROMO-5-HYDROXYMETHYLTHIAZOLE
• Synonyms: 2-Bromo-5-hydromethylthiazole;(2-Bromo-1,3-thiazol-5-yl)methanol 97%;2-Bromo-5-(hydroxymethyl)-1,3-thiazole;(2-bromothiazol-5-yl)methanol;2-Bromo-5-(hydroxymethyl)-1,3-thiazole 97%;2-Bromo-5-(hydroxymethyl)-1,3-thiazole97%;2-Bromo-5-thiazolemethanol;RARECHEM AL BD 1435
• CAS NO: 687636-93-7
• Molecular Formula: C₄H₄BrNOS
• Molecular Weight: 194.05
• EINECS: 200-589-5
• Product Categories: blocks;Bromides;Thiazoles;Building Blocks;Thiazole
• Mol File: 687636-93-7.mol
• Article Data: 18

Chemical Properties

• Melting Point: 46-48
• Boiling Point: 288.3°Cat760mmHg
• Flash Point: 128.1°C
• Appearance: /
• Density: 1.899g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.642
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 13.23±0.10(Predicted)
• CAS DataBase Reference: 2-BROMO-5-HYDROXYMETHYLTHIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-5-HYDROXYMETHYLTHIAZOLE(687636-93-7)
• EPA Substance Registry System: 2-BROMO-5-HYDROXYMETHYLTHIAZOLE(687636-93-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Hazardous Substances Data: 687636-93-7(Hazardous Substances Data)

Usage

General Description

2-Bromo-5-hydroxymethylthiazole is a chemical compound with the molecular formula C4H5BrNOS. It is a reactive intermediate that is commonly used in the production of pharmaceuticals and agrochemicals. 2-BROMO-5-HYDROXYMETHYLTHIAZOLE serves as a versatile building block for the synthesis of various heterocyclic compounds and has applications in medicinal chemistry and material science. It is known for its potent antimicrobial properties and is used as a starting material in the synthesis of pharmaceuticals, pesticides, and other bioactive molecules. Additionally, 2-Bromo-5-hydroxymethylthiazole is used in the synthesis of fluorescent dyes and inhibitors of bacterial enzymes.

InChI:InChI=1/C4H4BrNOS/c5-4-6-3(1-7)2-8-4/h2,7H,1H2

Upstream product

• 54045-74-8 methyl 2-bromo-1,3-thiazole-5-carboxylate 
• 464192-28-7 2-bromo-1,3-thiazole-5-carbaldehyde 
• 41731-83-3 ethyl 2-bromo-1,3-thiazole-5-carboxylate 

Downstream Products

• 131748-91-9 2-bromo-5-(bromomethyl)-1,3-thiazole 
• 464192-28-7 2-bromo-1,3-thiazole-5-carbaldehyde 
• 1052693-68-1 N-(5-{[(2-chlorophenyl)oxy]methyl}-1,3,4-thiadiazol-2-yl)-2-[5-(hydroxymethyl)-1,3-thiazol-2-yl]-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide 
• 1094621-83-6 5-(2-bromothiazol-5-ylmethoxy)-2,2,6,6-tetramethylcyclohex-4-ene-1,3-dione 

Relevant articles and documents

Fused tetracyclic compounds and application thereof in medicines

The invention relates to fused tetracyclic compounds and an application thereof in medicines, and in particular, relates to the application of the fused tetracyclic compounds as medicines for treatingand/or preventing hepatitis B. Specifically, the invention relates to the compounds represented by a general formula (I) or stereoisomers, tautomers, nitrogen oxides, solvates, metabolites, pharmaceutically acceptable salts or prodrugs thereof, wherein the variables are defined in the specification. The invention further relates to the application of the compounds represented by the general formula (I) or the stereoisomers, the tautomers, the nitric oxides, the solvates, the metabolites, the pharmaceutically acceptable salts or the prodrugs thereof as medicines, and in particular, relates tothe application of the compounds as the medicines for treating and/or preventing hepatitis B.

COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY

In one aspect, compounds of Formula A, or a pharmaceutically acceptable salt thereof, are featured (Formula A) or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.

Preparation method of 2-(2-bromo-1,3-thiazol-5-yl) acetonitrile

The invention discloses a preparation method of 2-(2-bromo-1,3-thiazol-5-yl) acetonitrile, which comprises the following steps: S1) adding a first organic solvent and methyl 2-bromothiazole-4-carboxylate into a reaction flask, cooling the mixture to 0 DEG C, adding sodium borohydride, reacting the mixture at room temperature, performing concentration and extraction, combining organic phases, and performing concentration and column chromatography separation to obtain 2-bromothiazole-5-methanol; S2) adding a second organic solvent and the 2-bromothiazole-5-methanol into a reaction bottle, cooling the mixture to 0 DEG C, adding phosphorus tribromide, washing a product with mother liquor, and performing concentration to obtain 2-bromo-5-bromomethyl-thiazole; S3) adding acetonitrile, the 2-bromo-5-bromomethyl-thiazole, potassium carbonate, tetrabutylammonium fluoride and TMSCN sequentially into a reaction flask, performing extraction, combining organic phases, and performing concentration and recrystallization to obtain the 2-(2-bromo-1,3-thiazol-5-yl) acetonitrile. The preparation method breaks through the blank at home and abroad, the preparation process and purification steps are safe and simple, and the preparation method is suitable for industrial production.