68768-34-3Relevant articles and documents
Total synthesis of the hypermodified RNA bases wybutosine and hydroxywybutosine and their quantification together with other modified RNA bases in plant materials
Hienzsch, Antje,Deiml, Christian,Reiter, Veronika,Carell, Thomas
, p. 4244 - 4248 (2013/04/23)
We report an efficient synthesis of the hypermodified natural tRNA modifications wybutosine (yW) and hydroxywybutosine (OHyW). We also describe the preparation of isotopically labeled analogues for precise quantification of yW and OHyW in different tissue
AN EFFICIENT SYNTHESIS OF Y-NUCLEOSIDE (WYOSINE) BY REGIOSPECIFIC METHYLATION OF N4-DESMETHYLWYOSINE USING ORGANOZINC REAGENT
Bazin, H.,Zhou, X-X.,Glemarec, C.,Chattopadhyaya, J.
, p. 3275 - 3278 (2007/10/02)
The reaction of the organozinc reagent, produced by the reaction of CH2I2 + Zn(C2H5)2 + glyme in diethylether at 20 deg C, regioselectively methylates the N4-nitrogen of N4-desmethylwyosine-triacetate 3 to give pure wyosine-triacetate 1e in 76percent isolated yield; no trace of the isomeric N5 methylated product is found in the latter reaction.Synthesis of a new congener of Y-nucleoside 1f is also reported for the first time from compound 5 in a high overall yield using a similar procedure.