68844-69-9

Basic information

• Product Name: (2R)-2-Hydroxy-4-phenylbutyric acid methyl ester
• Synonyms: (2R)-2-Hydroxy-4-phenylbutyric acid methyl ester
• CAS NO: 68844-69-9
• Molecular Weight: 194.23
• Mol File: 68844-69-9.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: (2R)-2-Hydroxy-4-phenylbutyric acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-2-Hydroxy-4-phenylbutyric acid methyl ester(68844-69-9)
• EPA Substance Registry System: (2R)-2-Hydroxy-4-phenylbutyric acid methyl ester(68844-69-9)

Safety Data

• Hazardous Substances Data: 68844-69-9(Hazardous Substances Data)

Upstream product

• 29678-81-7 (R)-2-hydroxy4-phenylbutanoic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 4263-93-8 2-hydroxy-4-phenylbutanoic acid 
• 108-05-4 vinyl acetate 
• 7226-82-6 (RS)-2-hydroxy-4-phenylbutanoic acid methyl ester 
• 121054-03-3 2-hydroxy-4-phenylbutanenitrile 
• 104-53-0 3-phenyl-propionaldehyde 
• 67-56-1 methanol 
• 130061-48-2 (3S,4R)-4-Chloro-1-phenyl-4-((R)-toluene-4-sulfinyl)-heptan-3-ol 
• 129990-71-2 (3R,4R)-4-Chloro-1-phenyl-4-((R)-toluene-4-sulfinyl)-heptan-3-ol 
• 129990-76-7 (R)-4-Chloro-1-phenyl-4-((R)-toluene-4-sulfinyl)-heptan-3-one 
• 245121-96-4 1,1-Dimethoxy-2-hydroxy-4-phenylbutyl-1-(diphenylphosphine oxide) 
• 85290-51-3 (S)-1-nitro-4-phenyl-2-butanol 
• 119072-55-8 tert-butylisonitrile 

Downstream Products

• 188774-81-4 (S)-2-Dibenzylamino-4-phenyl-butyric acid methyl ester 
• 138276-15-0 (R)-methyl 4-phenyl-2-{[(trifluoromethyl)sulfonyl]oxy}butanoate 
• 1027191-74-7 2-[4'-(2-benzyl-benzo[b]thiophen-3-yl)-3,5-dibromo-biphenyl-4-yloxy]-4-phenyl-butyric acid methyl ester 
• 473713-45-0 (S)-2-[4'-(2-Benzyl-benzofuran-3-yl)-biphenyl-4-yloxy]-4-phenyl-butyric acid methyl ester 
• 188774-87-0 (S)-2-Dibenzylamino-4-phenyl-butyric acid 

Relevant articles and documents

Chirality switching in the enantioseparation of 2-hydroxy-4-phenylbutyric acid: Role of solvents in selective crystallization of the diastereomeric salt

Chirality switching was induced by solvents in the enantioseparation of 2-hydroxy-4-phenylbutyric acid (HPBA) via diastereomeric salt formation with an enantiopure aminoalcohol. The (S)-salt was crystallized from butanol solutions and the (R)-salt was obt

Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors

The structure-based design, chemical synthesis and in vitro activity evaluation of various falcipain inhibitors derived from 2-pyridone are reported. These compounds contain a peptidomimetic binding determinant and a Michael acceptor terminal moiety capable of deactivating the cysteine protease active site.

The first catalytic, asymmetric α-additions of isocyanides. Lewis-base-catalyzed, enantioselective Passerini-type reactions

The first, catalytic, enantioselective α-additions of isocyanides to aldehydes have been demonstrated (Passerini-type reactions). The catalytic system of silicon tetrachloride and a chiral bisphosphoramide 5a provided high yields and good to excellent enantioselectivities for the addition of tert-butyl isocyanide to a wide range of aldehydes (aromatic, olefinic, acetylenic, aliphatic). Aqueous workup afforded the α-hydroxy tert-butyl amides, whereas methanolic quench followed by basic workup afforded the ∞-hydroxy methyl esters. Copyright