6887-59-8

Basic information

• Product Name: 1-methylpyridine-2(1H)-thione
• Synonyms: 1-Methylpyridine-2(1H)-thione; 2(1H)-pyridinethione, 1-methyl-
• CAS NO: 6887-59-8
• Molecular Formula: C₆H₇NS
• Molecular Weight: 125.1915
• Mol File: 6887-59-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 187.6°C at 760 mmHg
• Flash Point: 67.2°C
• Density: 1.16g/cm³
• Vapor Pressure: 0.626mmHg at 25°C
• Refractive Index: 1.636
• CAS DataBase Reference: 1-methylpyridine-2(1H)-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methylpyridine-2(1H)-thione(6887-59-8)
• EPA Substance Registry System: 1-methylpyridine-2(1H)-thione(6887-59-8)

Safety Data

• Hazardous Substances Data: 6887-59-8(Hazardous Substances Data)

Usage

Type of compound

Thione derivative of pyridine

Usage

Building block in the synthesis of pharmaceuticals and agrochemicals

Physical state

Colorless to pale yellow liquid

Odor

Strong, unpleasant

Solubility

Insoluble in water, soluble in most organic solvents

Applications

Organic synthesis, corrosion inhibitor in industrial processes

Safety precautions

Toxic, may cause skin, eye, and respiratory irritation

Handling

Handle with caution, use appropriate protective equipment

Upstream product

• 695-19-2 N-methyl-4-pyridone 
• 15592-05-9 4-chloro-1-methylpyridin-1-ium iodide 
• 52693-58-0 N-methyl-4-(methylsulfanyl)pyridinium iodide 
• 1120-93-0 pyran-4-thione 
• 74-89-5 methylamine 
• 22581-72-2 4-methylthiopyridine 

Downstream Products

• 126957-64-0 S-(1-Methyl-4-pyridyliden)-N-phenylsulfonylsulfimid 
• 126957-79-7 S-(1-Methyl-4-pyridinio)-N,N'-bis(phenylsulfonyl)sulfodiimidat 
• 126957-65-1 S-(1-Methyl-4-pyridyliden)-N-(p-toluolsulfonyl)sulfimid 
• 126957-71-9 S-(1-Methyl-4-pyridinio)-N,N'-bis(p-tolylsulfonyl)sulfodiimidat 
• 77148-83-5 4-Benzylthio-1-methylpyridinium bromide 
• 126957-66-2 N-(p-Chlorphenylsulfonyl)-S-(1-methyl-4-pyridyliden)sulfimid 
• 126957-80-0 N,N'-Bis(p-chlorphenylsulfonyl)-S-(1-methyl-4-pyridinio)sulfodiimidat 
• 126957-67-3 N-(p-Methoxyphenylsulfonyl)-S-(1-methyl-4-pyridyliden)sulfimid 
• 87577-85-3 4-(4-Chloro-benzylsulfanyl)-1-methyl-pyridinium; chloride 
• 15309-84-9 N-(1,4-Dihydro-1-methyl-4-pyridyliden)benzolsulfonamid 
• 15309-73-6 N-(1,4-Dihydro-1-methyl-4-pyridyliden)-p-methoxybenzolsulfonamid 
• 15362-61-5 N-(1-Methyl-4-pyridyliden)-p-chlorbenzolsulfonamid 
• 73572-69-7 Diphenylmethyl (6R,7R)-7-amino-3-(1-methylpyridinium-4-ylthiomethyl)-ceph-3-em-4-carboxylate bromide 

Relevant articles and documents

Anti-MRSA cephems. Part 2: C-7 cinnamic acid derivatives

Forty-five novel cephalosporin derivatives with activity against methicillin-resistant Staphylococcus aureus (MRSA) are described. The compounds contain novel cinnamic acid moieties at C-7 that were synthesized using a key Heck reaction followed by nucleophilic aromatic substitution reactions. The most active compound (41) displayed an MIC90 against MRSA of 1.0 μg/mL, and a PD50 of 0.8 mg/kg. Compound 14 was found to be very safe in a mouse model of acute toxicity.

REAKTIONEN VON THIOXOHETEROCYCLEN MIT N-CHLORAMIDEN II. N-SUBSTITUIERTE 2- ODER 4-THIOPYRIDONE UND NATRIUM-N-CHLORBENZOLSULFONAMIDE

N-Substituted 2- and 4-pyridinethiones A react with sodium-N-chlorobenzenesulfonamides 1 to N-phenylsulfonyl-S-pyridylidenesulfimides B, N,N'-bis(phenylsulfonyl)-S-pyridiniosulfodiimidates C and N-pyridylidenebenzenesulfonamides D.The constitution of the new pyridiniosulfodiimidates C is proved by X-ray crystal structure of one compound C and by 1H-NMR spectra of all 1-methylpyridinio-compounds C, which have a downfield shift for the N-methyl-δ-values.Formation, stabilities, IR-, 1H-NMR-spectra and bond systems of A-D are discussed.Key words: Pyridinethiones; sodium N-chlorobenzenesulfonamides; N-phenylsulfonyl-S-pyridylidenesulfimides; N,N'-bis(phenylsulfonyl)-S-pyridiniosulfodiimidates; N-pyridylidenebenzenesulfonamides; polarity of sulfur bonds.

Synthesis and reactions of heterocyclic dithiocarbamates

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