688763-89-5Relevant articles and documents
Structure-activity relationships of bivalent aminoglycosides and evaluation of their microbiological activities
Liang, Chang-Hsing,Romero, Alex,Rabuka, David,Sgarbi, Paulo W.M.,Marby, Kenneth A.,Duffield, Jonathan,Yao, Sulan,Cheng, Mayling L.,Ichikawa, Yoshi,Sears, Pamela,Hu, Changyong,Hwang, San-Bao,Shue, Youe-Kong,Sucheck, Steven J.
, p. 2123 - 2128 (2007/10/03)
A library of 4,5- and 4,6-linked bivalent aminoglycoside (AMG) antibiotics consisting of neamine and nebramine pharmacophores have been synthesized. We probed the effect of the linker on antibiotic activity with a series of selected synthetic analogues wi