688798-57-4

Basic information

• Product Name: 4-[(2-Bromophenyl)sulphonyl]morpholine
• Synonyms: 4-[(2-Bromophenyl)sulphonyl]morpholine;4-(2-Bromophenylsulfonyl)morpholine;4-(2-Bromobenzenesulfonyl)morpholine
• CAS NO: 688798-57-4
• Molecular Formula: C₁₀H₁₂BrNO₃S
• Molecular Weight: 306.18
• Product Categories: blocks;Bromides;Sulfonamides
• Mol File: 688798-57-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 426.224 °C at 760 mmHg
• Flash Point: 211.573 °C
• Appearance: /
• Density: 1.595 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.597
• Storage Temp.: Keep Cold
• CAS DataBase Reference: 4-[(2-Bromophenyl)sulphonyl]morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(2-Bromophenyl)sulphonyl]morpholine(688798-57-4)
• EPA Substance Registry System: 4-[(2-Bromophenyl)sulphonyl]morpholine(688798-57-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 688798-57-4(Hazardous Substances Data)

Usage

General Description

The chemical 4-[(2-Bromophenyl)sulphonyl]morpholine is a sulphonyl morpholine compound with a molecular formula of C11H12BrNO3S. It is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. The compound has a bromophenyl group attached to a morpholine ring, with a sulphonyl group also linked to the morpholine. 4-[(2-Bromophenyl)sulphonyl]morpholine is used in organic synthesis and medicinal chemistry as a versatile starting material for the preparation of various biologically active compounds. Its properties and structure make it a valuable and widely used chemical in the pharmaceutical and agrochemical industries.

InChI:InChI=1/C10H12BrNO3S/c11-9-3-1-2-4-10(9)16(13,14)12-5-7-15-8-6-12/h1-4H,5-8H2

Upstream product

• 110-91-8 morpholine 
• 2905-25-1 o-bromobenzenesulfonyl chloride 
• 108-86-1 bromobenzene 
• 60199-33-9 ortho-bromobenzenesulfonyl hydrazide 

Downstream Products

• 5033-21-6 4-benzenesulfonylmorpholine 
• 1610528-66-9 4-benzenesulfonyl-3,4-dihydro-2H-[1,4]oxazine 
• 1610528-67-0 1,2,4,4a-tetrahydro-3-oxa-9-thia-9a-azafluorene 9,9-dioxide 

Relevant articles and documents

AEROBIC OXIDATIVE SYNTHESIS OF SULFONAMIDE USING Cu CATALYST

The present invention relates to a method for oxidative synthesis of sulfonamides using copper catalysts. , Oxygen (O) is used. 2 The oxidative synthesis of sulfonamides (1) comprises reacting a 2 th or sulfonyl hydrazide primary amine with a sulfonyl hydrazide (sulfonamide) with a copper catalyst on a solvent under the conditions in which the sulphonamide is fed. The oxidation coupling of the present invention showed extensive substrate ranges in an amine comprising a 2 primary amine, 1 primary amine and amine hydrochloride salt. It is worth notable that non-reactive aliphatic sulfonyl hydrazides in previously reported anaerobic systems can be used for the aerobic oxidation coupling of the present invention. The oxidation coupling of the present invention has been more effective on large scale.

Iodine-catalyzed expeditious synthesis of sulfonamides from sulfonyl hydrazides and amines

A new synthesis of sulfonamides has been developed via an iodine-catalyzed sulfonylation of amines with arylsulfonyl hydrazides. This metal-free strategy employs readily accessible and easy to handle starting materials, catalysts and oxidants, and can be easily conducted under mild conditions, providing a convenient access to a wide range of sulfonamides in moderate to excellent yields within a short reaction time.

PHENETHANOLAMINE DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASES

The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.