688809-90-7Relevant articles and documents
Remote ester group leads to efficient kinetic resolution of racemic aliphatic alcohols via asymmetric hydrogenation
Yang, Xiao-Hui,Wang, Ke,Zhu, Shou-Fei,Xie, Jian-Hua,Zhou, Qi-Lin
, p. 17426 - 17429 (2015/02/02)
A highly efficient method for kinetic resolution of racemic aliphatic alcohols without conversion of the hydroxyl group has been realized; the method involves hydrogenation mediated by a remote ester group and is catalyzed by a chiral iridium complex. This powerful, environmentally friendly method provides chiral δ-alkyl-δ-hydroxy esters and δ-alkyl-1,5-diols in good yields with high enantioselectivities even at extremely low catalyst loading (0.001 mol %).