68883-08-9

Basic information

• Product Name: 1-Piperidinebutanol, a-(4-fluorophenyl)-4-methyl-
• Synonyms: FG5155; MDL 18664
• CAS NO: 68883-08-9
• Molecular Formula: C16H24 F N O
• Molecular Weight: 265.371
• Mol File: 68883-08-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-Piperidinebutanol, a-(4-fluorophenyl)-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinebutanol, a-(4-fluorophenyl)-4-methyl-(68883-08-9)
• EPA Substance Registry System: 1-Piperidinebutanol, a-(4-fluorophenyl)-4-methyl-(68883-08-9)

Safety Data

• Hazardous Substances Data: 68883-08-9(Hazardous Substances Data)

Upstream product

• 3874-54-2 4-(4-fluorophenyl)-4-oxo-n-butyl chloride 
• 626-58-4 4-methylpiperidin 
• 51787-87-2 (+/-)-4-chloro-1-(4-fluorophenyl)butan-1-ol 

Relevant articles and documents

Chemoenzymatic synthesis of (R)-(+)-α-(4-fluorophenyl)-4-(2-pyrimidinyl)-1-piperazinebutanol and (R)-(+)-α-(4-fluorophenyl)-4-methyl-1-piperidinebutanol as potential antipsychotic agents

A chemoenzymatic straightforward synthesis of (R)-(+)-α-(4-fluorophenyl)-4-methyl-1-piperidinebutanol (2) and (R)-(+)-α-(4-fluorophenyl)-4-(2-pyrimidinyl)-1-piperazinebutanol (3), two potential antipsychotic agents, has been developed by two different approaches involving lipase-mediated resolution of the racemic compounds or through asymmetrization of the precursor alcohol 4. A second enzymatic resolution followed by condensation of (R)-4 with 4-methylpiperidine (6) or 1-(2-pyrimidinyl)piperazine (7) leads to (R)-2 and (R)-3 in good chemical and excellent optical yields (>99% ee).