69039-02-7

Basic information

• Product Name: Hydroxytyrosol Acetate
• Synonyms: Hydroxytyrosol Acetate;2-(3,4-dihydroxy)Phenyl ethyl acetate;4-[2-(Acetyloxy)ethyl]-1,2-benzenediol;Hydroxy Tyrosol a-Acetate;3,4-dihydroxyphenethylacetate
• CAS NO: 69039-02-7
• Molecular Formula: C₁₀H₁₂O₄
• Molecular Weight: 196.201
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 69039-02-7.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 356℃
• Flash Point: 142℃
• Appearance: /
• Density: 1.260
• Vapor Pressure: 1.48E-05mmHg at 25°C
• Refractive Index: 1.563
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slig
• CAS DataBase Reference: Hydroxytyrosol Acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Hydroxytyrosol Acetate(69039-02-7)
• EPA Substance Registry System: Hydroxytyrosol Acetate(69039-02-7)

Safety Data

• Hazardous Substances Data: 69039-02-7(Hazardous Substances Data)

Usage

Uses

Hydroxytyrosol α-Acetate is a phenolic compound found in olive oil with antioxidant activity. Hydroxytyrosol α-Acetate contributes to the protective effects against oxidative stress of virgin olive oil.

InChI:InChI=1/C10H12O4/c1-7(11)14-5-4-8-2-3-9(12)10(13)6-8/h2-3,6,12-13H,4-5H2,1H3

Upstream product

• 86214-97-3 2-(3,4-diacetoxyphenyl)-ethyl acetate 
• 1043435-50-2 acetic acid 2-(2-methoxy-benzo[1,3]dioxol-5-yl)-ethyl ester 
• 32022-28-9 4-(2-acetoxyethyl)-2-methoxy-1-acetoxy-benzene 
• 108-05-4 vinyl acetate 
• 10597-60-1 hydroxytyrosol 
• 1043435-48-8 2-(2-methoxybanzo[1,3]dioxol-5-yl)-acetic acid methyl ester 
• 1043435-46-6 2-(2-methoxybanzo[1,3]dioxol-5-yl)-ethanol 
• 25379-88-8 2-(3,4-dihydroxyphenyl)acetic acid methyl ester 
• 96826-11-8 2-<3,4-bis(benzyloxy)phenyl>ethanol 
• 75-36-5 acetyl chloride 
• 141-78-6 ethyl acetate 
• 32619-42-4 oleuropeine 
• 58556-55-1 2-(4-hydroxyphenyl)ethyl acetate 
• 491845-54-6 2-(4'-hydroxyphenyl)ethyl hexanoate 

Downstream Products

• 10597-60-1 hydroxytyrosol 
• 1185745-16-7 2-[3′-hydroxy-4′-(methyl-2,3,4-tri-O-acetyl-β-D-glucopyranosyluronate)phenyl]ethyl acetate 
• 1185745-17-8 2-[4′-hydroxy-3′-(methyl-2,3,4-tri-O-acetyl-β-D-glucopyranosyluronate)phenyl]ethyl acetate 

Relevant articles and documents

Identification of hydroxytyrosyl oleate, a derivative of hydroxytyrosol with anti-inflammatory properties, in olive oil by-products

Hydroxytyrosyl esters with short, medium and long acyl chains were evaluated for their ability to reduce nitric oxide (NO) production by lipopolysaccharide-stimulated RAW264.7 macrophages. Among the compounds tested, C18 esters, namely hydroxytyrosyl stea

Antioxidant and Biological Activities of Hydroxytyrosol and Homovanillic Alcohol Obtained from Olive Mill Wastewaters of Extra-Virgin Olive Oil Production

Some constituents of the Mediterranean diet, such as extra-virgin olive oil (EVOO) contain substances such as hydroxytyrosol (HT) and its metabolite homovanillic alcohol (HA). HT has aroused much interest due to its antioxidant activity as a radical scavenger, whereas only a few studies have been made on the HA molecule. Both chemical synthesis and extraction techniques have been developed to obtain these molecules, with each method having its advantages and drawbacks. In this study, we report the use of tyrosol from olive mill wastewaters as a starting molecule to synthesize HT and HA, using a sustainable procedure characterized by high efficiency and low cost. The effects of HT and HA were evaluated on two cell lines, THP-1 human leukemic monocytes and L-6 myoblasts from rat skeletal muscle, after treating the cells with a radical generator. Both HT and HA efficiently inhibited ROS production. In particular, HT inhibited the proliferation of the THP-1 leukemic monocytes, while HA protected L-6 myoblasts from cytotoxicity.

Chemoenzymatic synthesis of hydroxytyrosol monoesters and their suppression effect on nitric oxide production stimulated by lipopolysaccharides

Fatty acid monoesters of hydroxytyrosol [2-(3,4-dihydroxyphenyl)ethanol] were synthesized in two steps from tyrosol (4-hydroxyphenylethanol) by successive Candida antarctica lipase B-catalyzed chemoselective acylation on the primary aliphatic hydroxy group over phenolic hydroxy group in tyrosol, and 2-iodoxybenzoic acid (IBX)-mediated hydroxylation adjacent to the remaining free phenolic hydroxy group. Examination of their suppression effects on nitric oxide production stimulated by lipopolysaccharides in RAW264.7 cells showed that hydroxytyrosol butyrate exhibited the highest inhibition (IC50 7.0 μM) among the tested compounds.