690633-28-4

Basic information

• Product Name: E-4-[1-(4-methoxybenzyl)-6-oxo-1,6-dihydropyridazin-3-yl]-but-3-enoic acid
• Synonyms: E-4-[1-(4-methoxybenzyl)-6-oxo-1,6-dihydropyridazin-3-yl]-but-3-enoic acid
• CAS NO: 690633-28-4
• Molecular Weight: 300.314
• Mol File: 690633-28-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: E-4-[1-(4-methoxybenzyl)-6-oxo-1,6-dihydropyridazin-3-yl]-but-3-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: E-4-[1-(4-methoxybenzyl)-6-oxo-1,6-dihydropyridazin-3-yl]-but-3-enoic acid(690633-28-4)
• EPA Substance Registry System: E-4-[1-(4-methoxybenzyl)-6-oxo-1,6-dihydropyridazin-3-yl]-but-3-enoic acid(690633-28-4)

Safety Data

• Hazardous Substances Data: 690633-28-4(Hazardous Substances Data)

Upstream product

• 51114-94-4 (2-carboxyethyl)triphenylphosphonium bromide 
• 673486-72-1 1-(4-methoxybenzyl)-6-oxo-1,6-dihydropyridazine-3-carbaldehyde 
• 673486-70-9 1-(4-methoxybenzyl)-6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylic acid methyl ester 
• 673486-71-0 1-(4-methoxybenzyl)-6-oxo-1,4,5,6-tetrahydropyridazine-3-methanol 
• 13192-04-6 dimethyl 2-ketoglutarate 
• 89532-94-5 methyl 6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylate 

Downstream Products

• 690633-29-5 N-(2-Boc-aminoethyl)-N-{4-[1-(4-methoxybenzyl)-6-oxo-1,6-dihydropyridazin-3-yl]-but-3-enoyl} glycine methyl ester 

Relevant articles and documents

Synthesis and evaluation of a conformationally constrained pyridazinone PNA-monomer for recognition of thymine in triple-helix structures

A novel conformationally constrained pyridazinone Eag-base PNA-monomer 2 capable of binding thymine in a triplex motif was designed and synthesised. A bis-PNA with the Eag-base incorporated in the Hoogsteen strand was hybridised with a complementary DNA. Thermal stability studies revealed an increase in Tm (4.3°C per mod.) compared to a no-base unit, but showed no improvement over a previously described unconstrained analogue (E, 1). Surprisingly, no significant difference was found in the thermodynamic parameters (ΔH°, ΔS° and ΔG°) for PNA-DNA triplex formation involving 2 or the unconstrained analogue 1.