69088-96-6 Usage
Description
4-(3-Aminophenyl)-2-methyl-3-butyn-2-ol is an organic compound that features a unique structure with an aminophenyl group attached to a butyn-2-ol moiety. This molecule is characterized by its potential reactivity and versatility in chemical synthesis, particularly in cross-coupling reactions.
Uses
Used in Chemical Synthesis Industry:
4-(3-Aminophenyl)-2-methyl-3-butyn-2-ol is used as a reactant in cross-coupling reactions for the synthesis of various aromatic and heteroaromatic compounds. Its presence in these reactions facilitates the formation of new carbon-carbon bonds, which is crucial for the creation of complex organic molecules and pharmaceutical intermediates.
In the context of cross-coupling reactions, this compound serves as a key intermediate, enabling the synthesis of a wide range of organic compounds with potential applications in various fields, including pharmaceuticals, agrochemicals, and materials science. The ability of 4-(3-Aminophenyl)-2-methyl-3-butyn-2-ol to participate in these reactions highlights its importance in modern organic chemistry and its contribution to the development of new and innovative chemical products.
Check Digit Verification of cas no
The CAS Registry Mumber 69088-96-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,9,0,8 and 8 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 69088-96:
(7*6)+(6*9)+(5*0)+(4*8)+(3*8)+(2*9)+(1*6)=176
176 % 10 = 6
So 69088-96-6 is a valid CAS Registry Number.
InChI:InChI=1/C11H13NO/c1-11(2,13)7-6-9-4-3-5-10(12)8-9/h3-5,8,13H,12H2,1-2H3
69088-96-6Relevant articles and documents
Fast heck-cassar-sonogashira (hcs) reactions in green solvents
Cabri, W.,Corbisiero, D.,Daka, A.,Fantoni, T.,Ferrazzano, L.,Martelli, G.,Ricci, A.,Tolomelli, A.,Viola, A.
supporting information, p. 3969 - 3973 (2020/06/08)
The replacement of toxic solvents with greener alternatives in Heck-Cassar-Sonogashira (HCS) cross-couplings was investigated. The fine-tuning of the HCS protocol allowed to achieve complete conversions and high speed under mild conditions. N-Hydroxyethylpyrrolidone (HEP) gave the best results. Moreover, the methodology was successfully applied to the synthesis of an intermediate of the anticancer drug Erlotinib, demonstrating the versatility of the new green protocol.
New method for the preparation of erlotinib
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, (2012/04/10)
The present invention refers to an alternative method for the preparation of Erlotinib through a new chemical reaction for the preparation of the 4-(3-aminophenyl)-2-methyl-3-butyn-2-ol key intermediate of formula (IV) according to the following scheme.
Process for preparing 3-aminophenylacetylenes
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Page/Page column 8; 9, (2008/06/13)
A process for preparing a 3-aminophenylacetylene compound of formula (5), including: a) reacting a 3-haloaniline compound of formula (1) with an acetylene compound of formula (2) in the presence of a palladium compound, a copper compound, and an amine compound of formula (3) to form an aniline compound of formula (4); b) precipitating the aniline compound of formula (4) in the form of a crystal, and isolating it by solid/liquid separation; and c) reacting the aniline compound of formula (4) with a base to obtain 3-aminophenylacetylene.
