691007-09-7

Basic information

• Product Name: Risperidone E-Oxime
• Synonyms: 3-[2-[4-[(E)-(2,4-Difluorophenyl)(hydroxyimino)methyl]-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one;Risperidone E-Oxime;3-[2-[4-[(E)-(2,4-Difluorophenyl)(hydroxyimino)methyl]-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-α]pyrimidin-4-one;Risperidone E-OxiMe IMpurity;Risperidone EP IMpurity A;3-[2-[4-[(E)-(2,4-difluorophenyl)(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one;Risperidone EP Impurity A -M
• CAS NO: 691007-09-7
• Molecular Formula: C₂₃H₂₈F₂N₄O₂
• Molecular Weight: 430.49
• Product Categories: Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Aromatics;Heterocycles
• Mol File: 691007-09-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 569°C at 760 mmHg
• Flash Point: 297.9°C
• Appearance: /
• Density: 1.34
• Vapor Pressure: 8.73E-14mmHg at 25°C
• Refractive Index: 1.63
• PKA: 10.74±0.70(Predicted)
• CAS DataBase Reference: Risperidone E-Oxime(CAS DataBase Reference)
• NIST Chemistry Reference: Risperidone E-Oxime(691007-09-7)
• EPA Substance Registry System: Risperidone E-Oxime(691007-09-7)

Safety Data

• Hazardous Substances Data: 691007-09-7(Hazardous Substances Data)

Usage

Description

Risperidone E-Oxime is an impurity derived from Risperidone (R525000), a pharmaceutical compound used in the treatment of various psychiatric disorders. It is characterized by its off-white powder appearance and is recognized as an impurity according to the United States Pharmacopeia (USP) standards.

Uses

Used in Pharmaceutical Industry:
Risperidone E-Oxime is used as an impurity reference for the quality control and assurance of Risperidone (R525000). Its identification and quantification are essential in ensuring the purity and safety of the final drug product, as impurities can affect the efficacy, safety, and stability of the medication.
Additionally, understanding the properties and behavior of Risperidone E-Oxime can contribute to the development of improved synthesis methods, purification techniques, and formulation strategies for Risperidone, ultimately enhancing the overall quality and performance of the drug.

InChI:InChI=1/C23H28F2N4O2/c1-15-18(23(30)29-10-3-2-4-21(29)26-15)9-13-28-11-7-16(8-12-28)22(27-31)19-6-5-17(24)14-20(19)25/h5-6,14,16,31H,2-4,7-13H2,1H3/b27-22+

Downstream Products

• 106266-06-2 Risperidone 

Relevant articles and documents

Process for making risperidone and intermediates therefor

The formation of risperidone is enhanced by the use of enriched Z-isomer oxime intermediate(s) of formula (3) or (7). The oxime(s) can be isomerically enriched by a variety of techniques including the use of the novel acetic acid salt thereof, which affords, inter alia, resolution of the isomers and/or by heat conversion.