6917-08-4

Basic information

• Product Name: N-(4-Methylphenyl)-4-nitrobenzamide
• Synonyms: N-(4-Methylphenyl)-4-nitrobenzamide;AF-936/31272009;ALD-N036573;Benzamide, 4-nitro-N-(4-methylphenyl)-;EU-0069677;Oprea1_097618;Oprea1_376667;ZINC00260683
• CAS NO: 6917-08-4
• Molecular Formula: C₁₄H₁₂N₂O₃
• Molecular Weight: 256.25668
• Mol File: 6917-08-4.mol
• Article Data: 29

Chemical Properties

• Melting Point: 201 °C
• Boiling Point: 354.1±35.0 °C(Predicted)
• Appearance: /
• Density: 1.304±0.06 g/cm3(Predicted)
• PKA: 12.16±0.70(Predicted)
• CAS DataBase Reference: N-(4-Methylphenyl)-4-nitrobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Methylphenyl)-4-nitrobenzamide(6917-08-4)
• EPA Substance Registry System: N-(4-Methylphenyl)-4-nitrobenzamide(6917-08-4)

Safety Data

• Hazardous Substances Data: 6917-08-4(Hazardous Substances Data)

Upstream product

• 106-49-0 p-toluidine 
• 122-04-3 4-nitro-benzoyl chloride 
• 62-23-7 4-nitro-benzoic acid 
• 540-23-8 p-toluidine hydrochloride 
• 3128-43-6 S-phenyl 4-nitrobenzothioate 
• 6631-86-3 S-(p-chlorophenyl) p-nitrothiobenzoate 
• 28122-84-1 4-nitrothiobenzoic acid S-p-tolyl ester 
• 69737-96-8 S-(p-nitrophenyl) p-nitrothiobenzoate 
• 83539-70-2 N-p-nitrobenzoyl-2-phenyliminooxazolidine 
• 81724-80-3 C₁₄H₁₂N₂O₃ 
• 86399-80-6 4-Nitro-N-(4-nitro-benzoyloxy)-N-p-tolyl-benzamide 
• 13144-36-0 4-Nitro-benzoic-<4-methoxy-benzylcarbonic>-anhydrid 
• 555-16-8 4-nitrobenzaldehdye 
• 1613-81-6 O-acetyl-4-nitrobenzohydroxamic acid 

Downstream Products

• 955-96-4 N-(4-methylphenyl)-4-aminobenzamide 
• 19717-14-7 4-(4-Nitrobenzoylamino)-benzoic acid 
• 303098-88-6 N-(4-methyl-2-nitrophenyl)-4-nitrobenzamide 
• 101351-39-7 2-acetoxy-4-(4-nitro-benzoylamino)-toluene 
• 860566-25-2 4-nitro-benzoic acid-(4-methyl-2,6-dinitro-anilide) 
• 254966-97-7 6-methyl-2-(4-nitro-phenyl)-4-phenyl-quinazoline 
• 90233-93-5 C₁₆H₁₉N₃O₃S 
• 36711-56-5 4-(4'-aminobenzamido)benzoic acid 
• 6393-42-6 4-methyl-2,6-dinitroaniline 
• 110178-74-0 4-(5-methyl-1H-benzimidazol-2yl)aniline 
• 571178-53-5 N-(4-methylphenyl)-4-nitrothiobenzamide 
• 619-80-7 4-nitrobenzamide 

Relevant articles and documents

Iron-catalyzed cross-coupling of N?methoxy amides and arylboronic acids for the synthesis of N-aryl amides

An efficient iron-catalyzed synthesis of N-aryl amides from N?methoxy amides and arylboronic acids is developed. FeCl3 is used as the sole catalyst for the cross-coupling reaction between N?methoxy amides and arylboronic acids without any other

Nitromethane as a nitrogen donor in Schmidt-type formation of amides and nitriles

The Schmidt reaction has been an efficient and widely used synthetic approach to amides and nitriles since its discovery in 1923. However, its application often entails the use of volatile, potentially explosive, and highly toxic azide reagents. Here, we report a sequence whereby triflic anhydride and formic and acetic acids activate the bulk chemical nitromethane to serve as a nitrogen donor in place of azides in Schmidt-like reactions. This protocol further expands the substrate scope to alkynes and simple alkyl benzenes for the preparation of amides and nitriles.

2-phenylpyrimidine compounds, preparation method and medical application

The invention belongs to the field of medicines and particularly relates to 2-phenylpyrimidine compounds and pharmacologically-acceptable salts thereof and an isotope marker. The invention also discloses a pharmaceutical composition containing the substances and application of the pharmaceutical composition for treating diseases related with protein kinase activity, such as cancer and inflammation. (The formula is shown in the description).