691857-54-2Relevant articles and documents
Convergent Synthesis of the NS5B Inhibitor GSK8175 Enabled by Transition Metal Catalysis
Arrington, Kenneth,Barcan, Gregg A.,Calandra, Nicholas A.,Erickson, Greg A.,Li, Ling,Liu, Li,Nilson, Mark G.,Strambeanu, Iulia I.,Vangelder, Kelsey F.,Woodard, John L.,Xie, Shiping,Allen, C. Liana,Kowalski, John A.,Leitch, David C.
, p. 4680 - 4694 (2019/04/30)
A convergent eight-stage synthesis of the boron-containing NS5B inhibitor GSK8175 is described. The previous route involves 13 steps in a completely linear sequence, with an overall 10% yield. Key issues include a multiday SNAr arylation of a s
THERAPEUTIC METHODS
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, (2013/03/26)
The present invention features a method for the treatment of Hepatitis C in a human in need thereof comprising administering a compound of Formulas (II) or (IIB) described herein or a pharmaceutically acceptable salt thereof in combination with one or more alternative Hepatitis C therapeutic agents
COMPOUNDS
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, (2012/06/01)
The present invention features compounds of formula (I): and salts thereof, pharmaceutical compositions comprising said compounds, and uses of such compounds in treating or preventing viral infections, such as HCV infections, and diseases associated with such infections.