691862-62-1Relevant articles and documents
Synthesis and in vitro antimycobacterial activity of novel 3-(1H-pyrrol-1-yl)-2-oxazolidinone analogues of PNU-100480
Sbardella, Gianluca,Mai, Antonello,Artico, Marino,Loddo, Roberta,Setzu, Maria Grazia,La Colla, Paolo
, p. 1537 - 1541 (2007/10/03)
Pursuing our search program for new antitubercular drugs we decided to explore the potentiality of oxazolidinone moiety by synthesizing novel 3-(1H-pyrrol-1-yl)-2-oxazolidinone analogues of PNU-100480. The new derivatives were tested against atypical mycobacteria as well as against drug resistant Mycobacterium tuberculosis and some of them exhibited a fairly good activity against Mycobacterium avium complex (MAC).
Polycondensed heterocycles. VII. A convenient synthesis of pyrrolo[1,2-a]quinoxaline derivatives by intramolecular aromatic nucleophilic displacement
Campiani,Nacci,Corelli,Anzini
, p. 1567 - 1576 (2007/10/02)
4-(4-Methyl-1-piperazinyl)-7- trifluoromethylpyrrolo[1,2-a]quinoxaline (CGS 12066B) and related analogs were prepared in good overall yield through a reaction sequence involving as a key step in the intramolecular substitution of aromatic fluoride or nitr