69193-11-9

Basic information

• Product Name: Z-L-Phe-L-Val-NH₂
• Synonyms: Z-L-Phe-L-Val-NH₂
• CAS NO: 69193-11-9
• Molecular Weight: 397.474
• Mol File: 69193-11-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Z-L-Phe-L-Val-NH₂(CAS DataBase Reference)
• NIST Chemistry Reference: Z-L-Phe-L-Val-NH₂(69193-11-9)
• EPA Substance Registry System: Z-L-Phe-L-Val-NH₂(69193-11-9)

Safety Data

• Hazardous Substances Data: 69193-11-9(Hazardous Substances Data)

Upstream product

• 13123-00-7 (2S)-2-[((2S)-2-{[(benzyloxy)carbonyl]amino}-3-phenylpropanoyl)amino]-3-methylbutanoic acid 
• 4816-89-1 Cbz-Phe-OCH₂CONH₂ 
• 3014-80-0 (S)-2-amino-3-methylbutanamide hydrochloride 
• 125453-25-0 [1-(1-Benzotriazol-1-yl-2-methyl-propylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester 
• 130457-37-3 [1-(1-Cyano-2-methyl-propylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester 
• 126028-14-6 2,2,2-trifluoroethyl ((benzyloxy)carbonyl)-L-phenylalaninate 
• 35909-92-3 N-carbobenzoxy-L-phenylalanine methyl ester 
• 1161-13-3 N-Cbz-L-Phe 
• 4540-60-7 L-valinamide 
• 3272-95-5 Z-L-Phe p-chlorophenyl ester 

Downstream Products

• 72-18-4 L-valine 
• 63-91-2 L-phenylalanine 
• 130457-28-2 1-<1-(N-benzyloxycarbonyl-phenylalanyl-valylamino)-3-methylbutyl>benzotriazole 
• 164861-48-7 Z-L-Phe-L-Val-L-Pro-NH₂ 
• 127536-33-8 N-benzyloxycarbonyl-L-phenylalanyl-L-valyl-D,L-leucine amide 
• 127536-32-7 {(R)-1-[(R)-1-((S)-1-Cyano-3-methyl-butylcarbamoyl)-2-methyl-propylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester 

Relevant articles and documents

Convenient primary amidation of N-protected phenylglycine and dipeptides without racemization or epimerization

Primary amidation of N-protected phenylglycine and dipeptide proceeded easily to afford the corresponding amides in 57-95% yields with 99% ee and 81-99% de, respectively. The procedure is very easy to avoid racemization and epimerization of the products in the reactions by keeping exactly the reaction temperature at -15 C when the activation of carboxylic acids, followed by the reaction of the mixed carbonic carboxylic anhydride with NH4Cl.

Pronase catalysed peptide syntheses

A mixture of proteases from Streptomyces griseus (pronase), displaying a very broad substrate tolerance in the hydrolysis of peptides, has been studied for the first time systematically regarding their substrate specificity in peptide synthesis. It is demonstrated that pronase can be employed successfully for the formation of dipeptides with yields up to 95%. Pronase has also been employed successfully as catalyst for the enzyme assisted synthesis of a hexapeptide.

Benzotriazole-assisted Synthesis of α-Acylaminonitriles and a Conceptually Novel Method for Peptide Elongation

A general method for the synthesis of α-acylamino nitriles is reported.Initially, the adducts resulting from Mannich-type condensation of benzotriazole with an aldehyde and an amide are prepared.These undergo elimination of benzotriazole with cyanide to g