69193-22-2

Basic information

• Product Name: 4-(piperidin-1-yl)pyrimidin-2-amine
• CAS NO: 69193-22-2
• Molecular Formula: C₉H₁₄N₄
• Molecular Weight: 178.2343
• Mol File: 69193-22-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 393°C at 760 mmHg
• Flash Point: 191.5°C
• Density: 1.184g/cm³
• Vapor Pressure: 2.2E-06mmHg at 25°C
• Refractive Index: 1.6
• CAS DataBase Reference: 4-(piperidin-1-yl)pyrimidin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(piperidin-1-yl)pyrimidin-2-amine(69193-22-2)
• EPA Substance Registry System: 4-(piperidin-1-yl)pyrimidin-2-amine(69193-22-2)

Safety Data

• Hazardous Substances Data: 69193-22-2(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 3993-78-0 2-amino-4-chloropyrimidine 

Relevant articles and documents

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2-PHENYLIMIDAZO[1,2-A]PYRIMIDINES AS IMAGING AGENTS

The present invention relates to compounds of general formula (I) wherein R1 is phenyl, optionally substituted by one or two substituents, selected from 3H, halogen, lower alkyl, di-methyl-amino, NHC(O)-lower alkyl, C(O)O-lower alkyl, lower alkoxy, OC(3H)3, O11CH3, OCH2CH218F, lower alkoxy substituted by halogen, hydroxy, lower alkyl substituted by hydroxy, S-lower alkyl, or by a heterocyclyl group; or is benzo[d][l,3]dioxol-5-yl, 2,3-dihydrobenzo[b][l,4]dioxin-6-yl, indolin-2-one, or is heteroaryl, selected from the group consisting of thiophenyl, benzofuranyl, benzothiophenyl, pyrazinyl, or benzothiazolyl; R2 is hydrogen, lower alkyl or lower alkyl substituted by halogen; R3 is lower alkyl, C(3H)3, 11CH3, lower alkyl substituted by halogen, -(CH2)2-O-lower alkyl substituted by halogen or cycloalkyl; or R2 and R3 form together with the N-atom to which they are attach a ring containing -CH2CH2CHRCH2CH2-, -CH2CH2CH2CH2-, -CH2CH2CH2CH2-, -CH2CH2-NR-CH2CH2-, -CH2CH2-O-CH2CH2-, -CH2CH2CHRCH2-, -CH2CHRCH2- or (A); R is hydrogen, halogen, lower alkyl substituted by halogen or lower alkoxy; or to a pharmaceutically acceptable acid addition salt, to a racemic mixture or to its corresponding enantiomer and/or optical isomers thereof. The compounds are suitable as imaging tool, which will improve diagnosis by identifying potential patients with excess of tau aggregates in the brain, which may be likely to develop Alzheimer' s disease.