692263-13-1

Basic information

• Product Name: C₂₀H₂₁NO
• Synonyms: C₂₀H₂₁NO
• CAS NO: 692263-13-1
• Molecular Weight: 291.393
• Mol File: 692263-13-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₂₁NO(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₂₁NO(692263-13-1)
• EPA Substance Registry System: C₂₀H₂₁NO(692263-13-1)

Safety Data

• Hazardous Substances Data: 692263-13-1(Hazardous Substances Data)

Upstream product

• 6296-61-3 N,N-diallylacetamide 
• 369-57-3 benzenediazonium tetrafluoroborate 

Downstream Products

• 150-59-4 alverine 
• 109418-64-6 N,N-bis(3-phenylpropyl)acetamide 

Relevant articles and documents

Construction of 3-arylpropylamines using Heck arylations. the total synthesis of cinacalcet hydrochloride, alverine, and tolpropamine

New synthetic routes toward the commercial drugs cinacalcet hydrochloride, alverine, and tolpropamine were developed using a Heck-Matsuda arylation as the key-step. Several reaction conditions were evaluated for the Heck-Matsuda reaction using allylamine derivatives and arenediazonium salts. For cinacalcet hydrochloride, N-formylamide provided the best result, furnishing the synthetic target in a very high overall yield (75% over five steps). For alverine, the best results were obtained using a double Heck-Matsuda strategy, providing alverine in an excellent overall yield (69%) from N-acetyl diallylamine in three steps. Tolpropamine was synthesized in a 46% yield over five steps using an efficient reductive Heck-Matsuda arylation between p-bromo-methylcinnamate with 3-chloro tolyldiazonium salt, generating the ,diaryl propionate that was converted to tolpropamine.