69249-22-5

Basic information

• Product Name: 6-broMo-1,2,4-triazin-3-aMine
• Synonyms: 6-broMo-1,2,4-triazin-3-aMine;6-BroMo-1,2,4-triazine-3-aMine;3-AMino-6-broMo-1,2,4-triazine;INC280-3;6-Bromo-[1,2,4]triazin-3-ylamine
• CAS NO: 69249-22-5
• Molecular Formula: C₃H₃BrN₄
• Molecular Weight: 174.98672
• Product Categories: Heterocycle-other series
• Mol File: 69249-22-5.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 373.6 °C at 760 mmHg
• Flash Point: 179.7 °C
• Appearance: /
• Density: 1.998 g/cm³
• Vapor Pressure: 8.86E-06mmHg at 25°C
• Refractive Index: 1.663
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.02±0.63(Predicted)
• CAS DataBase Reference: 6-broMo-1,2,4-triazin-3-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-broMo-1,2,4-triazin-3-aMine(69249-22-5)
• EPA Substance Registry System: 6-broMo-1,2,4-triazin-3-aMine(69249-22-5)

Safety Data

• Hazardous Substances Data: 69249-22-5(Hazardous Substances Data)

Usage

Flammability and Explosibility

Flammable

InChI:InChI=1/C3H3BrN4/c4-2-1-6-3(5)8-7-2/h1H,(H2,5,6,8)

Upstream product

• 1120-99-6 3-amino-1,2,4-triazine 
• 67-56-1 methanol 

Downstream Products

• 104405-59-6 3,5-diamino-6-bromo-1,2,4-triazine 
• 1197377-47-1 4-(3-amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile 
• 1332952-09-6 4-(3-amino-1,2,4-triazin-6-yl)-N,2-dimethylbenzamide 
• 1332951-93-5 methyl 4-(3-amino-1,2,4-triazin-6-yl)-2-chlorobenzoate 
• 18915-36-1 3-amino-6-methyl-1,2,4-triazine 
• 1029715-91-0 methyl 4-(3-amino-1,2,4-triazin-6-yl)benzoate 
• 942-72-3 3-amino-6-phenyl-1,2,4-triazine 
• 1029714-96-2 4-(3-amino-1,2,4-triazin-6-yl)-2-fluoro-benzoic acid methyl ester 

Relevant articles and documents

C-H-Functionalization of 1,2,4-triazines: Oxidation and elimination pathways of aromatization of σh-adducts

An approach to the synthesis of 1,2,4-triazine thienyl and furyl derivatives through the reaction of aromatic nucleophilic substitution of hydrogen was suggested. Oxidation and cine-elimination pathways of aromatization of the intermediate σH-a

(HETERO)ARYLAMIDE COMPOUND FOR INHIBITING PROTEIN KINASE ACTIVITY

Provided are a (hetero)arylamide compound as shown in formula (I) having an inhibitory effect on protein kinase activity, a pharmaceutically acceptable salt, a stereoisomer, a solvate or hydrate thereof, a pharmaceutical composition comprising the compound or a derivative thereof, and a method for preparing the compound. The compound can be used as an irreversible inhibitor for protein kinase for preparing a plurality of drugs comprising an anti-tumour drug.

Improved method for synthetizing lamotrigine

The invention discloses an improved method for synthetizing lamotrigine. The method comprises the following steps: step I, carrying out helogenating reaction through 3-amino-1,2,4-triazine (I) and a halogenating reagent in the presence of an organic solvent to obtain 3-amino 6-halogeno-1,2,4-triazine (II); step II, carrying out amination reaction of a compound II to prepare 3,5-diamino 6-halogeno-1,2,4-triazine (compound III); and step III, carrying out suzuki coupling reaction through the compound III and 2,3-dichlorobenzene boric acid derivative in the solvent under catalysis of palladium/[N,N] pyridine amidino ligand/alkali to prepare lamotrigine (IV). Through the method, metal cyanide is not used; meanwhile, the method is high in reaction selectivity and high in reaction yield.