692755-52-5Relevant articles and documents
Synthesis and Biological Activity of Sulfonamide Derivatives of Epipodophyllotoxin
Guianvarc'h, Dominique,Duca, Maria,Boukarim, Chawki,Kraus-Berthier, Laurence,Léonce, Stéphane,Pierré, Alain,Pfeiffer, Bruno,Renard, Pierre,Arimondo, Paola B.,Monneret, Claude,Dauzonne, Daniel
, p. 2365 - 2374 (2007/10/03)
A series of novel 4β-substituted sulfonamide derivatives of 4′-O-demethyl-4-desoxypodophyllotoxin has been synthesized. Their effects on human DNA topoisomerase II and, in some cases, on tubulin polymerization were evaluated. Compounds 8a, 8c, 8f, 8g, 8n,