69300-16-9

Basic information

• Product Name: 3-(4-(tert-butyl)phenyl)propanenitrile
• Synonyms: 3-(4-(tert-butyl)phenyl)propanenitrile
• CAS NO: 69300-16-9
• Molecular Weight: 187.285
• Mol File: 69300-16-9.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 3-(4-(tert-butyl)phenyl)propanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-(tert-butyl)phenyl)propanenitrile(69300-16-9)
• EPA Substance Registry System: 3-(4-(tert-butyl)phenyl)propanenitrile(69300-16-9)

Safety Data

• Hazardous Substances Data: 69300-16-9(Hazardous Substances Data)

Upstream product

• 2537-48-6 diethyl 1-cyanomethylphosphonate 
• 939-97-9 4-tert-Butylbenzaldehyde 
• 19158-51-1 P-toluenesulfonyl cyanide 
• 1624333-27-2 potassium (4-(tert-butyl)phenethyl)trifluoroborate 
• 1746-23-2 4-tert-Butylstyrene 
• 23741-79-9 Isopropylmalonsauredinitril 
• 107-13-1 acrylonitrile 
• 98-73-7 4-(1,1-dimethylethyl)benzoic acid 
• 123324-71-0 p-tert-butylphenylboronic acid 
• 877-65-6 p-tert-butylbenzyl alcohol 
• 75-05-8 acetonitrile 

Downstream Products

• 800395-53-3 4-tert-Butylphenylpropylamine 
• 18127-01-0 3-(4-tert-butylphenyl)propionaldehyde 

Relevant articles and documents

Overcoming Selectivity Issues in Reversible Catalysis: A Transfer Hydrocyanation Exhibiting High Kinetic Control

Reversible catalytic reactions operate under thermodynamic control, and thus, establishing a selective catalytic system poses a considerable challenge. Herein, we report a reversible transfer hydrocyanation protocol that exhibits high selectivity for the thermodynamically less favorable branched isomer. Selectivity is achieved by exploiting the lower barrier for C-CN oxidative addition and reductive elimination at benzylic positions in the absence of a cocatalytic Lewis acid. Through the design of a novel type of HCN donor, a practical, branched-selective, HCN-free transfer hydrocyanation was realized. The synthetically useful resolution of a mixture of branched and linear nitrile isomers was also demonstrated to underline the value of reversible and selective transfer reactions. In a broader context, this work demonstrates that high kinetic selectivity can be achieved in reversible transfer reactions, thus opening new horizons for their synthetic applications.

A strategy for generating aryl radicals from arylborates through organic photoredox catalysis: Photo-Meerwein type arylation of electron-deficient alkenes

Photoinduced reactions of arylboronic acids with electron deficient alkenes under mild organic photoredox catalysis conditions lead to the formation of Meerwein arylation type adducts via the generation of aryl radicals.

Deboronative cyanation of potassium alkyltrifluoroborates: Via photoredox catalysis

A photoredox catalytic method was developed for the direct cyanation of alkyltrifluoroborates. This reaction provides a new and useful transformation of the easily available alkyltrifluoroborates. The photocatalytic reaction can tolerate a variety of functional groups with mild reaction conditions. Mechanistic investigations are consistent with the present reaction following a radical pathway.