69316-09-2

Basic information

• Product Name: 3-(3,5-dichlorophenyl)-3-oxopropanenitrile
• Synonyms: 3-(3,5-dichlorophenyl)-3-oxopropanenitrile;UKRORGSYN-BB BBV-073763
• CAS NO: 69316-09-2
• Molecular Formula: C₉H₅Cl₂NO
• Molecular Weight: 214.05
• Mol File: 69316-09-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 393.3°C at 760 mmHg
• Flash Point: 191.7°C
• Appearance: /
• Density: 1.383g/cm³
• Vapor Pressure: 2.15E-06mmHg at 25°C
• Refractive Index: 1.567
• CAS DataBase Reference: 3-(3,5-dichlorophenyl)-3-oxopropanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,5-dichlorophenyl)-3-oxopropanenitrile(69316-09-2)
• EPA Substance Registry System: 3-(3,5-dichlorophenyl)-3-oxopropanenitrile(69316-09-2)

Safety Data

• Hazardous Substances Data: 69316-09-2(Hazardous Substances Data)

Usage

General Description

3-(3,5-dichlorophenyl)-3-oxopropanenitrile is a chemical compound with the molecular formula C9H4Cl2N. It is also known as fenvalerate, and it is a synthetic pyrethroid insecticide that is commonly used in agricultural and household pest control. Fenvalerate works by disrupting the nervous system of insects, leading to paralysis and ultimately their death. It is effective against a wide range of pests, including mosquitoes, flies, cockroaches, and ants. However, it is also highly toxic to fish and other aquatic organisms, so it should be used with caution near water sources. Fenvalerate is available in various formulations, including sprays, dusts, and emulsifiable concentrates, and it is commonly used in combination with other insecticides for enhanced efficacy.

InChI:InChI=1/C9H5Cl2NO/c10-7-3-6(4-8(11)5-7)9(13)1-2-12/h3-5H,1H2

Upstream product

• 91085-56-2 3,5-dichlorobenzoic acid ethyl ester 
• 75-05-8 acetonitrile 
• 18293-53-3 2-trimethylsilylacetonitrile 
• 3032-81-3 3,5-dichloroiodobenzene 
• 13939-06-5 molybdenum hexacarbonyl 

Downstream Products

• 69316-22-9 3-(3,5-Dichlor-phenyl)-2-oximino-3-oxo-propionitril 
• 92406-45-6 5-(3,5-Dichloro-phenyl)-2-methyl-2H-pyrazol-3-ylamine 
• 907190-89-0 3-(3,5-dichlorophenyl)-1-(2-naphthyl)-1H-pyrazol-5-amine 
• 907190-93-6 N-[3-(3,5-dichlorophenyl)-1-(2-naphthyl)-1H-pyrazol-5-yl]-β-alanine 
• 929294-12-2 3-[5-(3,5-dichloro-phenyl)-2-naphthalen-2-yl-2H-pyrazol-3-ylamino]-propionic acid ethyl ester 
• 92406-26-3 methyl 3-(3,5-dichlorophenyl)-1,6-dimethyl-4-(3-nitrophenyl)-4,7-dihydropyrazolo[3,4-b]pyridine-5-carboxylate 
• 1195951-29-1 C₁₆H₁₀Cl₂F₃N₃O 
• 766520-00-7 5-(3,5-dichloro-phenyl)-2H-pyrazol-3-ylamine 
• 1195951-31-5 C₂₃H₁₄Cl₂F₃N₃O₃ 
• 1195951-30-4 C₂₇H₂₂Cl₂F₃N₃O₃ 
• 1195951-35-9 C₂₈H₂₄Cl₂F₃N₃O₃ 
• 1195951-34-8 C₂₄H₁₅Cl₂F₃N₈O₂ 
• 1195951-33-7 C₂₆H₁₉Cl₂F₃N₄O₄ 
• 1195951-37-1 C₂₇H₂₁Cl₂F₃N₄O₄ 

Relevant articles and documents

One-pot synthesis of benzoylacetonitriles through sequential Pd-catalyzed carbonylation and decarboxylation

Benzoylacetonitrile were prepared through sequential carbonylation and decarboxylation. The palladium-catalyzed carbonylation of aryl iodides and methyl cyanoacetate using Mo(CO)6 as a carbon monoxide source afforded beta-keto cyanoesters, and then the subsequent reaction with Li/H2O produced the desired benzoylacetonitriles.

Design, synthesis, and evaluation of 2-aryl-7-(3′,4′-dialkoxyphenyl)-pyrazolo[1,5-a]pyrimidines as novel PDE-4 inhibitors

Described herein is design, synthesis, and biological evaluation of novel series of 2-aryl-7-(3′,4′-dialkoxyphenyl)-pyrazolo[1,5-a]pyrimidines acting as inhibitors of type 4 phosphodiesterase (PDE4) which is known as a good target for the treatment of asthma and COPD. For this purpose, structure optimization was conducted with the aid of structure-based drug design using the known X-ray crystallography. Also, biological effects of these compounds on the target enzyme were evaluated by using in vitro assays, leading to the potent and selective PDE-4 inhibitor (IC50 10 nM).