69321-32-0

Basic information

• Product Name: 2-(2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetyl)-N-p-tolylhydrazinecarbothioamide
• Synonyms: 2-(2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetyl)-N-p-tolylhydrazinecarbothioamide
• CAS NO: 69321-32-0
• Molecular Weight: 397.455
• Mol File: 69321-32-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetyl)-N-p-tolylhydrazinecarbothioamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetyl)-N-p-tolylhydrazinecarbothioamide(69321-32-0)
• EPA Substance Registry System: 2-(2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetyl)-N-p-tolylhydrazinecarbothioamide(69321-32-0)

Safety Data

• Hazardous Substances Data: 69321-32-0(Hazardous Substances Data)

Upstream product

• 5614-82-4 ethyl 2-(4-methyl-2-oxo-2-coumarin-7-yloxy)acetate 
• 90-33-5 7-hydroxy-4-methyl-chromen-2-one 
• 69321-36-4 2-(4-methyl-2-oxo-2H-chromen-7-yloxy)-acetohydrazide 
• 622-59-3 1-isothiocyanato-4-methylbenzene 

Downstream Products

• 1429303-04-7 ?(Z)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)-N-(4-oxo-2-(p-tolylimino)thiazolidin-3-yl)acetamide 
• 69560-71-0 7-((5-mercapto-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)methoxy)-4-methyl-2H-chromen-2-one 

Relevant articles and documents

Synthesis and antimicrobial activities of some triazole, thiadiazole, and oxadiazole substituted coumarins

Ethyl-2-(4-methyl-2-oxo-2-coumarin-7-yloxy)acetate 1 has been prepared from 7-hydroxy-4-methyl-2-coumarin, which on further treatment with hydrazine hydrate in boiling ethanol gave the hydrazide compound 2. The resulting hydrazide was reacted with substituted aryl isothiocyanates to form thiosemicarbazides compounds 3a, 3b, 3c, 3d, 3e. 1-(2-(4-Methyl-2-oxo-2- coumarin-7-yloxy)acetyl)-4-aryl thiosemicarbazides 3 underwent cyclization with different reagents under different reaction conditions to furnish coumarin derivatives possessing triazoles 4a, 4b, 4c, 4d, 4e, thiadiazoles 5a, 5b, 5c, 5d, 5e, and oxadiazoles 6a, 6b, 6c, 6d, 6e, respectively. The structures of all the compounds have been assigned by elemental analysis and spectral studies. The synthesized compounds were screened for their antimicrobial analgesic activities. The nonconventional controlled microwave irradiation synthesis is carried out at (200 W) at 70°C. This approach offers a number of advantages in terms of methodology, high-product yield, short reaction time, mild reaction conditions, environmentally benign, and easy workup.

Synthesis of substituted coumarinyloxy triazoles and thiadiazoles and their antimicrobial activity

Hydrazides and thiosemicarbazides of substituted coumarins have been synthesised by condensing substituted carbethoxy coumarins with hydrazine hydrate and aryl isothiocyanates respectively.The thiosemicarbazides when cyclised on treatment with NaOH and conc.H2SO4 give triazoles and thiadiazoles.The synthesised compounds have been tested for their anti-microbial activity against Alternaria brassicicola, Fusarium udam, Staphylococcus gram (-ve), Lactobacilus gram (-ve).However none of them show any significant activity.