693285-70-0

Basic information

• Product Name: 1-Propanone, 1-(2-bromo-6-fluorophenyl)-2-methyl-
• CAS NO: 693285-70-0
• Molecular Formula: C10H10BrFO
• Molecular Weight: 245.091
• Mol File: 693285-70-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 1-(2-bromo-6-fluorophenyl)-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 1-(2-bromo-6-fluorophenyl)-2-methyl-(693285-70-0)
• EPA Substance Registry System: 1-Propanone, 1-(2-bromo-6-fluorophenyl)-2-methyl-(693285-70-0)

Safety Data

• Hazardous Substances Data: 693285-70-0(Hazardous Substances Data)

Upstream product

• 360575-28-6 2-bromo-6-fluorobenzaldehyde 
• 1068-55-9 isopropylmagnesium chloride 
• 1073-06-9 3-fluorobromobenzene 

Downstream Products

• 693285-71-1 4-bromo-3-isopropyl-1H-indazole 

Relevant articles and documents

3-ARYL-5,6-DISUBSTITUTED PYRIDAZINES

The present invention provides compounds of Formula (I) or (II) salt form or prodrug thereof, wherein variables are defined herein, that are modulators of metalloproteases such as matrix metalloproteases (MMPs) and ADAMs. The compounds or compositions described herein can be used to treat diseases associated with metalloprotease activity including, for example, arthritis, cancer, cardiovascular disorders, skin disorders, inflammation or allergic conditions.

4,5-DISUBSTITUTED-2-ARYL PYRIMIDINES

4,5-disubstituted-2-arylpyrimidines of Formula (I) and Formula (II) are provided: wherein R1, R2, R3, R8, R9, A and Ar are defined herein. Such compounds are ligands of C5a receptors. Preferred compounds of Formula I and II bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse activity at C5a receptors. The present invention also relates to pharmaceutical compositions comprising such compounds, and to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. In addition, the present invention provides labeled 4,5-disubstituted-2-arylpyrimidines, which are useful as probes for the localization of C5a receptors.