6935-15-5

Basic information

• Product Name: 4-{[(benzyloxy)carbonyl]amino}-2-hydroxybenzoic acid
• CAS NO: 6935-15-5
• Molecular Formula: C₁₅H₁₃NO₅
• Molecular Weight: 287.2674
• Mol File: 6935-15-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 450.3°C at 760 mmHg
• Flash Point: 226.2°C
• Density: 1.432g/cm³
• Vapor Pressure: 6.75E-09mmHg at 25°C
• Refractive Index: 1.677
• CAS DataBase Reference: 4-{[(benzyloxy)carbonyl]amino}-2-hydroxybenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-{[(benzyloxy)carbonyl]amino}-2-hydroxybenzoic acid(6935-15-5)
• EPA Substance Registry System: 4-{[(benzyloxy)carbonyl]amino}-2-hydroxybenzoic acid(6935-15-5)

Safety Data

• Hazardous Substances Data: 6935-15-5(Hazardous Substances Data)

Upstream product

• 133-10-8 sodium p-aminosalicylate 
• 501-53-1 benzyl chloroformate 
• 65-49-6 4-Aminosalicylic acid 

Downstream Products

• 98804-62-7 7-benzyloxycarbonylamino-2,2-dimethyl-benzo[1,3]dioxin-4-one 
• 842137-44-4 7-amino-2,2-dimethylbenzo[1,3]dioxin-4-one 
• 1391921-95-1 N-(4-methoxycarbonyl-3-methoxyphenylcarbamoylmethyl)-N,N',N'',N''-diethylenetriaminetetraacetic acid 
• 27492-84-8 Methyl 4-amino-2-methoxybenzoate 
• 89565-76-4 methyl 4-(benzyloxycarbonylamino)-2-methoxybenzoate 

Relevant articles and documents

Synthesis and hybrid sar property modeling of novel cholinesterase inhibitors?

A library of novel 4‐{[(benzyloxy)carbonyl]amino}‐2‐hydroxybenzoic acid amides was designed and synthesized in order to provide potential acetyl‐ and butyrylcholinesterase (AChE/BChE) inhibitors; the in vitro inhibitory profile and selectivity index were

Salicylic-acid derivatives as antennae for ratiometric luminescent probes based on lanthanide complexes

Long-lived ratiometric sensors: Luminescent lanthanide complexes are widely used in time-resolved assays of biomolecules, but most of the sensors with these complexes rely on single-point intensity measurements. Herein, we introduce a simple strategy to create ratiometric probes by using salicylic-acid derivatives as the antenna moiety of Tb3+ complexes. As an example, a probe for alkaline phosphatase (ALP) was developed (see scheme). Copyright

5′-O-[(N-acyl)sulfamoyl]adenosines as antitubercular agents that inhibit MbtA: An adenylation enzyme required for siderophore biosynthesis of the mycobactins

A study of the structure - activity relationships of 5′-O-[N- (salicyl)sulfamoyl]adenosine (6), a potent inhibitor of the bifunctional enzyme salicyl-AMP ligase (MbtA, encoded by the gene Rv2384) in Mycobacterium tuberculosis, is described, targeting the salicyl moiety. A systematic series of analogues was prepared exploring the importance of substitution at the C-2 position revealing that a hydroxy group is required for optimal activity. Examination of a series of substituted salicyl derivatives indicated that substitution at C-4 was tolerated. Consequently, a series of analogues at this position provided 4-fluoro derivative, which displayed an impressive MIC 99 of 0.098 μM against whole-cell M. tuberculosis under iron-limiting conditions. Examination of other heterocyclic, cycloalkyl, alkyl, and aminoacyl replacements of the salicyl moiety demonstrated that these nonconserative modifications were poorly tolerated, a result consistent with the fairly strict substrate specificities of related non-ribosomal peptide synthetase adenylation enzymes.