69358-84-5Relevant articles and documents
Deconjugative alkylation/Heck reaction as a simple platform for dihydronaphthalene synthesis
Navaratne, Primali V.,Grenning, Alexander J.
, p. 69 - 75 (2017)
A simple platform for carbocycle synthesis by Knoevenagel adduct deconjugative alkylation/Heck reaction is described. Deconjugative alkylation of Knoevenagels adducts is two-fold synthetically enabling because C-C bond formation is (1) operationally simple due to the ease of Knoevenagel adduct carbanion generation and (2) results in alkene migration, which poises the substrate for cyclization. Furthermore, the gem-dinitrile moiety serves as a functional group for synthetic manipulation.
