69422-72-6

Basic information

• Product Name: 2,4,6-TRICHLORONICOTINIC ACID
• Synonyms: 2,4,6-TRICHLORONICOTINIC ACID;2,4,6-Trichloropyridine-3-carboxylic acid;2,4,6-Trichloropyridine-3-carboxylic Acid 97%;2,4,6-Trichloro-3-pyridinecarboxylic acid
• CAS NO: 69422-72-6
• Molecular Formula: C₆H₂Cl₃NO₂
• Molecular Weight: 226.44458
• Mol File: 69422-72-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 357.4 °C at 760 mmHg
• Flash Point: 169.9 °C
• Appearance: /
• Density: 1.728 g/cm³
• Vapor Pressure: 9.98E-06mmHg at 25°C
• Refractive Index: 1.618
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.49±0.28(Predicted)
• CAS DataBase Reference: 2,4,6-TRICHLORONICOTINIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-TRICHLORONICOTINIC ACID(69422-72-6)
• EPA Substance Registry System: 2,4,6-TRICHLORONICOTINIC ACID(69422-72-6)

Safety Data

• Hazardous Substances Data: 69422-72-6(Hazardous Substances Data)

Usage

General Description

2,4,6-Trichloronicotinic acid is a chemical compound that belongs to the class of pyridine carboxylic acids. It is mainly used as a herbicide and plant growth regulator, and it is particularly effective in controlling the growth of broadleaf weeds and invasive plant species. 2,4,6-TRICHLORONICOTINIC ACID disrupts the photosynthesis process in the target plants, leading to their eventual death. 2,4,6-Trichloronicotinic acid is also used in research and laboratory settings as a building block in the synthesis of various pharmaceutical and agrochemical compounds. Additionally, it is known to have low toxicity to mammals and has a relatively low environmental impact when used as a herbicide.

InChI:InChI=1/C6H2Cl3NO2/c7-2-1-3(8)10-5(9)4(2)6(11)12/h1H,(H,11,12)

Upstream product

• 16063-69-7 2,4,6-trichloropyridine 
• 124-38-9 carbon dioxide 
• 2587-00-0 2,6-dichloropyridine N-oxide 
• 2402-78-0 2,6-dichloropyridine 

Downstream Products

• 69422-73-7 2,4,6-trichloronicotinoyl chloride 
• 1390656-56-0 tert-butyl 4-(4-(8-chloro-5-oxo-2,3,4,5-tetrahydro-1H-pyrido[2,3-e][1,4]diazepin-6-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate 
• 1390655-14-7 8-(2,6-dichlorobenzyl)-6-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}-1,2,3,4-tetrahydro-5H-pyrido[2,3-e][1,4]diazepin-5-one 
• 1390656-57-1 tert-butyl 4-(4-(8-chloro-5-oxo-2,3,4,5-tetrahydro-1H-pyrido[2,3-e][1,4]diazepin-6-ylamino)phenyl)piperazine-1-carboxylate 
• 1390655-15-8 8-(2,6-dichlorobenzyl)-6-{[4-(piperazin-1-yl)phenyl]amino}-1,2,3,4-tetrahydro-5H-pyrido[2,3-e][1,4]diazepin-5-one 
• 1390656-61-7 tert-butyl 4-(4-(8-chloro-5-oxo-2,3,4,5-tetrahydro-1H-pyrido[4,3-e][1,4]diazepin-6-ylamino)phenyl)piperazine-1-carboxylate 
• 1390655-18-1 8-(2,6-dichlorobenzyl)-6-(4-(piperazin-1-yl)phenylamino)-1,2,3,4-tetrahydropyrido[4,3-e][1,4]diazepin-5-one 
• 1391001-28-7 tert-butyl 4-(4-(7-chloro-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-5-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate 

Relevant articles and documents

BICYCLIC INHIBITORS OF ALK

The present invention relates to compounds of formula (1) or pharmaceutical acceptable salts, Formula (1) wherein R1, R2, R3, X, Y, Z, A, B, G1, m, and n are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.

BICYCLIC INHIBITORS OF ANAPHASTIC LYMPHOMA KINASE

Disclosed are compounds of formula (Ⅰ) and their pharmaceutical acceptable salts, wherein R1, R2, R3, X, Y, Z, A, B, G1, m and n are defined in the description. The compositions containing the said compounds used for inhibiting kinases such as anaphastic lymphoma kinase (ALK) and methods of treating diseases such as cancer are disclosed.

Synthesis and Structure-Activity Relationships of Novel 7-Substituted 1,4-Dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic Acids as Antitumor Agents. Part 2

We have previously reported that a series of 7-substituted 6-fluoro-1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acids possess moderate cytotoxic activity. In a further attempt to find clinically useful antitumor agents, we investigated the structure-activity relationships (SARs) of a new series of compounds obtained by changing the C-6 position of the fluorine atom in addition to the C-5 and C-7 positions and evaluating their cytotoxic activity against several murine and human tumor cell lines. Our results showed that the 6-unsubstituted 1,8-naphthyridine structure had the most potent cytotoxic activity against murine P388 leukemia twice that of the 6-fluoro analogue. In addition, introduction of an amino group at the C-5 position did not have any substantial effect on the cytotoxic activity, while both the 5-chloro and 5-trifluoromethyl groups decreased the cytotoxic activity by 5- to 10-fold. Moreover, aminopyrrolidine derivatives at the C-7 position showed more potent cytotoxic activity than other amines or carbon derivatives. Among the 7-(3-aminopyrrolidinyl) derivatives, the trans-3-methoxy-4-methylaminopyrrolidinyl derivative (271) was determined to have potent cytotoxic activity in both in vitro and in vivo assays and high water solubility. Finally, the (S,S)-isomer (AG-7352, 3) of 271, with a cytotoxic activity against human tumor cell lines more potent than that of etoposide, was selected for further development.