69440-99-9

Basic information

• Product Name: Thymalfasin
• Synonyms: Thymalfasin;L-Asparagine, N-acetyl-L-seryl-L-alpha-aspartyl-L-alanyl-L-alanyl-L-valyl-L-alpha-asparatyl-L-threonyl-L-seryl-L-seryl-L-alpha-glutamyl-L-isoleucyl-L-threonyl-L-threonyl-L-lysyl-L-alpha-aspartyl-L-leucyl-L-lysyl-L-alpha-glutamyl-L-lysyl-L-lysyl-L-alpha-glutamyl-L-valyl-L-valyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alanyl-L-alpha-glutamyl-;Thymosin alpha1 (cattle);Thymosin alpha1 (human);Thymosin alpha1 (ox)
• CAS NO: 69440-99-9
• Molecular Formula: C129H215N33O55
• Molecular Weight: 3108.3142
• EINECS: 1592732-453-0
• Mol File: 69440-99-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Thymalfasin(CAS DataBase Reference)
• NIST Chemistry Reference: Thymalfasin(69440-99-9)
• EPA Substance Registry System: Thymalfasin(69440-99-9)

Safety Data

• Hazardous Substances Data: 69440-99-9(Hazardous Substances Data)

Usage

Uses

Zadax- in (SciClone).

Relevant articles and documents

Solid phase process for synthesizing peptides

Thymosin α1 and other peptide amides are synthesized in the solid phase using methylbenzhydrylamine resin as the support and hydrogen bromide as the deprotecting and cleaving agents. The N-terminal 14 amino acid partial sequence of thymosin α1, Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-OH is synthesized on benzyl ester resin. Using a mixture of hydrogen bromide, anisole and thioanisole as the cleavage and deprotection composition, the yields of the cleaved peptide and the selectivity of the deprotection is highly improved. For example, yields of thymosin α1 have been increased by about 90% as compared to the use of hydrogen bromide alone. By using hydrogen bromide rather than hydrogen fluoride, the synthesis can use conventional laboratory glassware and the synthesis can be easily scaled up to commercial production.