69454-54-2Relevant articles and documents
A safe and efficacious Pt(ii) anticancer prodrug: Design, synthesis,: In vitro efficacy, the role of carrier ligands and in vivo tumour growth inhibition
Dutta, Pradip Kumar,Sharma, Rupali,Kumari, Smita,Dubey, Ravindra Dhar,Sarkar, Sujit,Paulraj, Justin,Vijaykumar, Gonela,Pandey, Manoj,Sravanti,Samarla, Mallik,Das, Hari Sankar,Yashpal,Heeralal,Goyal, Ravinder,Gupta, Nimish,Mandal, Swadhin K.,Sengupta, Aniruddha,Sarkar, Arindam
, p. 1718 - 1721 (2019)
Diaminocyclohexane-Pt(ii)-phenalenyl complexes (1 and 2) showed an appropriate balance between efficacy and toxicity. Compound 2 showed nearly two-fold higher tumour growth inhibition than oxaliplatin in a murine NSCLC tumour model, when a combined drug development approach was used. The fluorescent properties of phenalenone were utilized to understand the mechanistic details of the drug.
1,9-Disubstituted phenalenes-I. Synthesis of n- and s-derivatives of 9-hydroxy-1-phenalenone
Franz,Martin
, p. 2147 - 2151 (2007/10/06)
The reaction of 9-hydroxy-1-phenalenone with Ag2O and alkyliodides gives the analogous β-keto-ethers from which synthetic pathways have been devised to isolate and characterise some nitrogen and sulphur derivatives. As intermediates stable phenalenium cations can be isolated by the reaction of 9-substituted 1-phenalenones with [(C2H5)3O]+BF4-. Whenever possible, a strong intramolecular H-bond is formed between the 1-and 9-substituents as shown by the low-field resonances of the respective hydrogens in the 1H NMR and the stability of the compounds towards reduction.
