6949-23-1 Usage
Description
4-METHYL-3-NITROBENZENESULFONAMIDE is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its chemical structure, which includes a methyl group at the 4-position and a nitro group at the 3-position, attached to a benzene ring with a sulfonamide functional group.
Uses
Used in Pharmaceutical Industry:
4-METHYL-3-NITROBENZENESULFONAMIDE is used as an intermediate for the preparation of α-keto amide inhibitors of hepatitis C virus NS3 protease. These inhibitors play a significant role in the development of antiviral drugs targeting the hepatitis C virus, contributing to the treatment and management of the disease.
Additionally, 4-METHYL-3-NITROBENZENESULFONAMIDE is used to synthesize 1,4-diazepane-3,5-dione derivatives. These derivatives have potential applications in the prevention and treatment of various diseases associated with chymase, an enzyme involved in inflammatory processes and other physiological functions. By targeting chymase, these derivatives can help in the development of therapeutic agents for conditions such as asthma, allergic rhinitis, and other inflammatory diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 6949-23-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,9,4 and 9 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 6949-23:
(6*6)+(5*9)+(4*4)+(3*9)+(2*2)+(1*3)=131
131 % 10 = 1
So 6949-23-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H8N2O4S/c1-5-2-3-6(14(8,12)13)4-7(5)9(10)11/h2-4H,1H3,(H2,8,12,13)
6949-23-1Relevant articles and documents
TGF-beta receptor inhibitor
-
Paragraph 0142-0144; 0151-0152, (2021/04/28)
The invention provides a compound shown as a formula (I) and a pharmaceutical composition thereof. The compound shown as the formula (I) of the present invention is useful as a TGF-beta receptor inhibitor, particularly a TGF beta RI inhibitor, for example, in the prevention or treatment of various TGF beta RI (ALK5) mediated related diseases.
REACTION OF ORGANIC AZIDES WITH UNSATURATED COMPOUNDS XI. REARRANGEMENTS OF BICYCLIC TRIAZOLINES, OBTAINED FROM TAUTOMERIC 2,4,4-TRIMETHYL-AND 3,3,5-TRIMETHYL-1-METHOXYCYCLOPENTENES AND 4-METHYL-3-NITROBENZENESULFONYL AZIDE
Semenov, V. P.,Ogloblin, K. A.
, p. 711 - 715 (2007/10/02)
The reaction of 4-methyl-3-nitrobenzenesulfonyl azide with the tautomeric 2,4,4-trimethyl- and 3,3,5-trimethyl-1-methoxycyclopentenes leads to the formation of the products from transformation of both triazolines in almost equal ratios.The less substituted triazoline is converted through the corresponding aziridine into the allylsulfonamide, while the more substituted triazoline rearranges preferentially to methyl N-arylsulfonyl-1,3,3-trimethylcyclobutanecarboximidate.