6950-82-9 Usage
Description
7-HYDROXYCOUMARIN-4-ACETIC ACID is an organic compound with the molecular formula C9H6O5. It is a derivative of coumarin, which is a class of organic compounds that are characterized by their fused benzene and pyran rings. This particular compound has a hydroxyl group at the 7th position and an acetic acid group at the 4th position, which gives it unique properties and potential applications in various fields.
Uses
Used in Fluorescence Labeling:
7-HYDROXYCOUMARIN-4-ACETIC ACID is used as a fluorescence label for various applications, such as in biochemistry and molecular biology. Its fluorescence properties allow it to be used for detecting and tracking specific molecules or biological processes.
Used as a pH Indicator:
7-HYDROXYCOUMARIN-4-ACETIC ACID can also be used as a pH indicator due to its ability to change its properties in response to changes in the pH of its environment. This makes it useful in various chemical and biological applications where monitoring pH levels is important.
Used in Enzyme Substrate Synthesis:
In the field of biochemistry, 7-HYDROXYCOUMARIN-4-ACETIC ACID is used in the synthesis of novel and specific enzyme substrates for Maroteaux-Lamy (MPS VI) and Morquio A (MPS IVA) diseases. These substrates are essential for the study and treatment of these genetic disorders.
Used in MALDI-TOF MS:
7-HYDROXYCOUMARIN-4-ACETIC ACID is employed as an ionic liquid matrix for Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) of proteins, peptides, and carbohydrates. This technique is widely used in proteomics and other areas of research to analyze and identify biomolecules based on their mass-to-charge ratio.
Check Digit Verification of cas no
The CAS Registry Mumber 6950-82-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,9,5 and 0 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 6950-82:
(6*6)+(5*9)+(4*5)+(3*0)+(2*8)+(1*2)=119
119 % 10 = 9
So 6950-82-9 is a valid CAS Registry Number.
InChI:InChI=1/C11H8O5/c12-7-1-2-8-6(3-10(13)14)4-11(15)16-9(8)5-7/h1-2,4-5,12H,3H2,(H,13,14)
6950-82-9Relevant articles and documents
Pivalase catalytic antibodies: Towards abzymatic activation of prodrugs
Bensel, Nicolas,Reymond, Martine T.,Reymond, Jean-Louis
, p. 4604 - 4612 (2007/10/03)
Screening of monoclonal-an-tibody libraries generated against the tert-butyl phosphonate hapten 2 and the chloromethyl phosphonate hapten 3 with pivaloyloxymethyl-umbelliferone 1 as a fluorogenic substrate led to the isolation of eleven catalytic antibodies with rate accelerations around kcat/kuncat=103. The antibodies are not inhibited by the product and accept different acyloxymethyl derivatives of acidic phenols as substrates. The highest activity was found for the bulky, chemically less-reactive pivaloyloxymethyl group; there is no activity with acetoxymethyl or acetyl esters. This difference might reflect the preference of the immune system for hydrophobic interactions in binding and catalysis. Pivalase catalytic antibodies might be useful for activating orally available pivaloyloxymethyl prodrugs.
