6951-34-4Relevant articles and documents
Mammalian metabolism of phencyclidine
Baker,Wohlford,Bradbury,Wirth
, p. 666 - 669 (1981)
In dogs, the major metabolite of phencyclidine was found to be 5-[N-(1'-phenylcyclohexyl) amino]pentanoic acid (1). The γ-aminobutyric acid like metabolite was also pharmacologically evaluated to determine if the purported GABA-ergic mediated effects of p
Indirect monoalkylation of primary and secondary amines by reductive decyanation of α-aminonitriles with sodium cyanoborohydride-mercury bis(trifluoroacetate)
Sassaman, Mark B.
, p. 10835 - 10840 (2007/10/03)
Secondary and tertiary amines are prepared from α-aminonitriles by selective reductive cleavage of the cyanide moiety. The α-aminonitriles in this case, function as 'masked' imine or iminium ions and are 'unmasked' by mercury(II) in the presence of sodium cyanoborohydride to obtain the reduced product. Secondary amines may be prepared indirectly from primary amines in good yield without danger of over alkylation.