695172-13-5

Basic information

• Product Name: diphenyl ((N-benzyloxycarbonyl-O-tert-butyl-D-seryl)-L-alanyl)amino-(4-(N,N'-bis(tert-butyloxycarbonyl)guanyl)butyl)methanephosphonate
• Synonyms: diphenyl ((N-benzyloxycarbonyl-O-tert-butyl-D-seryl)-L-alanyl)amino-(4-(N,N'-bis(tert-butyloxycarbonyl)guanyl)butyl)methanephosphonate
• CAS NO: 695172-13-5
• Molecular Weight: 925.029
• Mol File: 695172-13-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: diphenyl ((N-benzyloxycarbonyl-O-tert-butyl-D-seryl)-L-alanyl)amino-(4-(N,N'-bis(tert-butyloxycarbonyl)guanyl)butyl)methanephosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: diphenyl ((N-benzyloxycarbonyl-O-tert-butyl-D-seryl)-L-alanyl)amino-(4-(N,N'-bis(tert-butyloxycarbonyl)guanyl)butyl)methanephosphonate(695172-13-5)
• EPA Substance Registry System: diphenyl ((N-benzyloxycarbonyl-O-tert-butyl-D-seryl)-L-alanyl)amino-(4-(N,N'-bis(tert-butyloxycarbonyl)guanyl)butyl)methanephosphonate(695172-13-5)

Safety Data

• Hazardous Substances Data: 695172-13-5(Hazardous Substances Data)

Upstream product

• 65806-90-8 (R)-2-(((benzyloxy)carbonyl)amino)-3-(tert-butoxy)propanoic acid 
• 695172-06-6 diphenyl (N-benzyloxycarbonyl-L-alanyl)amino-(4-(N,N'-bis(tert-butyloxycarbonyl)guanyl)butyl)methanephosphonate 
• 695171-99-4 diphenyl N-benzyloxycarbonylamino-(4-(N,N'-bis(tert-butyloxycarbonyl)guanyl)butyl)methanephosphonate 
• 152120-54-2 (Z)-tert-butyl (((tert-butoxycarbonyl)imino)(1H-pyrazol-1-yl)methyl)carbamate 
• 149194-44-5 diphenyl benzyloxycarbonylamino-(4-phthalimidobutyl)methanephosphonate 
• 149194-47-8 (5-Amino-1-benzyloxycarbonylamino-pentyl)-phosphonic acid diphenyl ester 
• 63273-48-3 5-phthalimido-1-pentanol 
• 95691-09-1 5-phthalimido-1-pentanal 
• 2508-29-4 5-hydroxypentylamine 
• 101-02-0 triphenyl phosphite 

Relevant articles and documents

Development of Irreversible Diphenyl Phosphonate Inhibitors for Urokinase Plasminogen Activator

In this letter we report the synthesis and biochemical evaluation of selective, irreversible diphenyl phosphonate inhibitors for urokinase plasminogen activator (uPA). A diphenyl phosphonate group was introduced on the substratelike peptide Z-D-Ser-Ala-Arg, and modification of the guanidine side chain was investigated. A guanylated benzyl group appeared the most promising side chain modification. A kapp value in the 103 M -1 s-1 range for uPA was obtained, together with a selectivity index higher than 240 toward other trypsin-like proteases such as tPA, thrombin, plasmin, and FXa.