695177-56-1Relevant articles and documents
Efficient methods for glycosidations with glycals - A key intermediate for the synthesis of mucin core 1-type O-glycan
Geiger, Jürgen,Barroca, Nadine,Schmidt
, p. 836 - 840 (2007/10/03)
The use of glycals as acceptors in glycosylation reactions is hampered by their sensitivity to acids. We report here on the successful use of mild Lewis acid [Sn(OTf)2] as catalyst for the glycosylation with O-glycosyl trichloroacetimidates and on the development of this method to construct a key intermediate for the synthesis of mucin type O-glycans. To this end, chemoselective nitration of O-glycosylated glycals, stereoselective threonine addition, and reduction of the nitro group to the amino group by an efficient procedure avoiding the use of an expensive catalyst was performed.