6952-13-2 Usage
Description
5-NITRO-3-INDOLYLACETONITRILE, also known as 5-Nitro-3-indolyl acetonitrile, is an organic compound with the chemical formula C9H6N2O2. It is a yellow solid and is primarily used in organic synthesis due to its unique chemical properties.
Uses
Used in Organic Synthesis:
5-NITRO-3-INDOLYLACETONITRILE is used as a synthetic building block for the creation of various organic compounds. Its chemical structure allows it to be a versatile intermediate in the synthesis of a wide range of molecules, including pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-NITRO-3-INDOLYLACETONITRILE is used as a key intermediate in the development of new drugs. Its unique chemical properties make it a valuable component in the synthesis of various therapeutic agents, potentially contributing to the treatment of various diseases and medical conditions.
Used in Agrochemical Industry:
5-NITRO-3-INDOLYLACETONITRILE is also utilized in the agrochemical industry for the synthesis of active ingredients in pesticides and other crop protection products. Its incorporation into these compounds can help improve the effectiveness of these products in protecting crops from pests and diseases.
Used in Dye and Pigment Industry:
In the dye and pigment industry, 5-NITRO-3-INDOLYLACETONITRILE is used as a starting material for the production of various dyes and pigments. Its yellow color and chemical properties make it a suitable candidate for the development of new colorants for use in various applications, such as textiles, plastics, and printing inks.
Used in Research and Development:
5-NITRO-3-INDOLYLACETONITRILE is also used in research and development laboratories for the study of its chemical properties and potential applications. Scientists and researchers use this compound to explore new reaction pathways, develop novel synthetic methods, and investigate its potential use in various fields, including materials science, nanotechnology, and biotechnology.
Check Digit Verification of cas no
The CAS Registry Mumber 6952-13-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,9,5 and 2 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 6952-13:
(6*6)+(5*9)+(4*5)+(3*2)+(2*1)+(1*3)=112
112 % 10 = 2
So 6952-13-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H7N3O2/c11-4-3-7-6-12-10-2-1-8(13(14)15)5-9(7)10/h1-2,5-6,12H,3H2
6952-13-2Relevant articles and documents
Discovery of the cancer cell selective dual acting anti-cancer agent (Z)-2-(1H-indol-3-yl)-3-(isoquinolin-5-yl)acrylonitrile (A131)
See, Cheng Shang,Kitagawa, Mayumi,Liao, Pei-Ju,Lee, Kyung Hee,Wong, Jasmine,Lee, Sang Hyun,Dymock, Brian W.
, p. 344 - 367 (2018/07/25)
Selective targeting of cancer cells over normal cells is a key objective of targeted therapy. However few approaches achieve true mechanistic selectivity resulting in debilitating side effects and dose limitation. In this work we describe the discovery of A131 (4a), a new agent with an unprecedented dual mechanism of action targeting both mitosis and autophagy. Compound 4a was first identified in a phenotypic screen in which HeLa cells treated with 4a manifested mitotic arrest along with formation of multiple vesicles. Further investigations showed that 4a causes an increase in mitotic marker pH3 and autophagy marker LC3. Importantly 4a induces cell death in cancer cells while sparing normal cells which regrow after 4a is removed. Dual activities against pH3 and LC3 markers are required for cancer cell selectivity. An extensive SAR investigation confirmed 4a as the optimal dual inhibitor with potency against a panel of 30 cancer cell lines (average antiproliferative GI50 1.5 μM). In a mouse model of paclitaxel-resistant colon cancer, 4a showed 74% tumor growth inhibition when administered at a dose of 20 mg/kg IP twice a day.
5-Nitro-3-(methoxymethyl)indole from the Cyanation of 5-Nitrogramine: Mechanistic Implications
Russell, Henry F.,Waller, Eric J.,Ducharme, Norman R.
, p. 871 - 872 (2007/10/02)
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