6952-34-7

Basic information

• Product Name: 2-(4-HYDROXYPHENYL)QUINOLINE-4-CARBOXYLIC ACID
• Synonyms: AKOS B000548;2-(4-HYDROXYPHENYL)QUINOLINE-4-CARBOXYLIC ACID;CHEMBRDG-BB 5349475;TIMTEC-BB SBB001025;4-quinolinecarboxylic acid, 2-(4-hydroxyphenyl)-;2-(4-hydroxyphenyl)quinoline-4-carboxylic acid(SALTDATA: FREE)
• CAS NO: 6952-34-7
• Molecular Formula: C₁₆H₁₁NO₃
• Molecular Weight: 265.26
• Mol File: 6952-34-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 500.997 °C at 760 mmHg
• Flash Point: 256.794 °C
• Appearance: /
• Density: 1.374 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.712
• CAS DataBase Reference: 2-(4-HYDROXYPHENYL)QUINOLINE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-HYDROXYPHENYL)QUINOLINE-4-CARBOXYLIC ACID(6952-34-7)
• EPA Substance Registry System: 2-(4-HYDROXYPHENYL)QUINOLINE-4-CARBOXYLIC ACID(6952-34-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 6952-34-7(Hazardous Substances Data)

Usage

General Description

2-(4-Hydroxyphenyl)quinoline-4-carboxylic acid is a chemical compound with the molecular formula C17H11NO3. It is a derivative of quinoline and contains a carboxylic acid functional group and a hydroxyphenyl group. 2-(4-HYDROXYPHENYL)QUINOLINE-4-CARBOXYLIC ACID is often used in pharmaceutical research and drug development due to its potential pharmacological properties. It has been studied as a potential anti-cancer agent and has shown activity against various cancer cell lines in experimental studies. Additionally, 2-(4-Hydroxyphenyl)quinoline-4-carboxylic acid has also been investigated for its potential as an antimicrobial and antiviral agent. Its unique chemical structure and potential biological activities make it a subject of interest in the field of medicinal chemistry and drug discovery.

InChI:InChI=1/C16H11NO3/c18-11-7-5-10(6-8-11)15-9-13(16(19)20)12-3-1-2-4-14(12)17-15/h1-9,18H,(H,19,20)

Upstream product

• 4364-02-7 2-(4-methoxyphenyl)quinoline-4-carboxylic acid 
• 91-56-5 indole-2,3-dione 
• 99-93-4 4-Hydroxyacetophenone 
• 123-08-0 4-hydroxy-benzaldehyde 
• 127-17-3 2-oxo-propionic acid 
• 62-53-3 aniline 
• 99-90-1 para-bromoacetophenone 
• 103914-52-9 2-(4'-bromophenyl)quinoline-4-carboxylic acid 
• 350997-62-5 methyl 2-(4'-bromophenyl)-quinoline-4-carboxylate 

Downstream Products

• 30696-03-8 2-(4-hydroxyphenyl)quinoline 
• 39654-23-4 2-(4-hydroxy-phenyl)-1-methyl-quinolinium; iodide 

Relevant articles and documents

A new boronic acid based fluorescent reporter for catechol

Catechol skeleton widely exists in natural products and bioactive substances. Fluorescent reporters which could recognize catechol are very promising for the construction of chemosensors to detect catechol and its derivatives in biological environment. Herein, we reported a novel catechol reporter, 2-(4-boronophenyl)quinoline-4-carboxylic acid, which exhibits significant fluorescent property changes upon binding catechol containing molecules in an aqueous solution.

A highly selective and sensitive boronic acid-based sensor for detecting Pd2+ ion under mild conditions

Herein, a boronic acid-based sensor was reported selectively to recognize Pd2+ ion. The fluorescence intensity increased 36-fold after sensor binding with 2.47 × 10?5 M of Pd2+ ion. It was carried out in the 99% aqueous so

Synthesis, characterization, and antileishmanial activity of certain quinoline-4-carboxylic acids

Leishmaniasis is a fatal neglected parasitic disease caused by protozoa of the genus Leishmania and transmitted to humans by different species of phlebotomine sandflies. The disease incidence continues to increase due to lack of vaccines and prophylactic drugs. Drugs commonly used for the treatment are frequently toxic and highly expensive. The problem of these drugs is further complicated by the development of resistance. Thus, there is an urgent need to develop new antileishmanial drug candidates. The aim of this study was to synthesize certain quinoline-4-carboxylic acids, confirm their chemical structures, and evaluate their antileishmanial activity. Pfitzinger reaction was employed to synthesize fifteen quinoline-4-carboxylic acids (Q1-Q15) by reacting equimolar mixtures of isatin derivatives and appropriate α-methyl ketone. The products were purified, and their respective chemical structures were deduced using various spectral tools (IR, MS, 1H NMR, and 13C NMR). Then, they were investigated against L. donovani promastigote (clinical isolate) in different concentration levels (200 μg/mL to 1.56 μg/mL) against sodium stibogluconate and amphotericin B as positive controls. The IC50 for each compound was determined and manipulated statistically. Among these compounds, Q1 (2-methylquinoline-4-carboxylic acid) was found to be the most active in terms of IC50.