69584-88-9Relevant articles and documents
1'-methylspiro[indoline-3,4'-piperidine] derivatives: Design, synthesis, molecular docking and anti-tumor activity studies
Li, Junjian,Ye, Lianbao,Wang, Yuanyuan,Liu, Ying,Jin, Xiaobao,Li, Ming
, p. 490 - 498 (2021/10/02)
Background: Spirocyclic indoline compounds widely exist in numerous natural products and synthetic molecules with significant biological activities. In recent years, these kinds of compounds have attracted extensive attention as potent anti-tumor agents i
Novel Tetracyclic Spiropiperidines. II. Synthesis of 2-Aryl-2,3-dihydrospiro
Ong, Helen H.,Agnew, Marc N.
, p. 815 - 820 (2007/10/02)
A series of 2-aryl-2,3-dihydrospiro has been synthesized as potential psychotropic agents via an efficient intramolecular fluorine displacement reaction.Treatment of a key intermediate, 4-cyano-4-(2-fluorophenyl)-1-methylpiperidine (2), with a large excess of phenylmagnesium bromide in refluxing tetrahydrofuran led to some 2-arylspiro derivatives, 10 and 11, whose structures are elucidated on the basis of chemical and spectral evidence.