6959-89-3

Basic information

• Product Name: Benzoicacid, 3,4,5-trimethoxy-, 2-acetylphenyl ester
• Synonyms: Benzoicacid, 3,4,5-trimethoxy-, 2-acetylphenyl ester
• CAS NO: 6959-89-3
• Molecular Formula: C₁₈H₁₈O₆
• Molecular Weight: 330.33192
• Mol File: 6959-89-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 443.2°Cat760mmHg
• Flash Point: 194.4°C
• Appearance: /
• Density: 1.195g/cm³
• Vapor Pressure: 4.72E-08mmHg at 25°C
• Refractive Index: 1.549
• CAS DataBase Reference: Benzoicacid, 3,4,5-trimethoxy-, 2-acetylphenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoicacid, 3,4,5-trimethoxy-, 2-acetylphenyl ester(6959-89-3)
• EPA Substance Registry System: Benzoicacid, 3,4,5-trimethoxy-, 2-acetylphenyl ester(6959-89-3)

Safety Data

• Hazardous Substances Data: 6959-89-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C18H18O6/c1-11(19)13-7-5-6-8-14(13)24-18(20)12-9-15(21-2)17(23-4)16(10-12)22-3/h5-10H,1-4H3

Upstream product

• 118-93-4 o-hydroxyacetophenone 
• 4521-61-3 3,4,5-Trimethoxybenzoyl chloride 

Downstream Products

• 1394018-43-9 3-hydroxy-1-(2-hydroxyphenyl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 
• 1394018-44-0 2-fluoro-3-hydroxy-1-(2-hydroxyphenyl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 
• 1394018-31-5 3-fluoro-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one 
• 143468-23-9 3-Nitro-2-(3,4,5-trimethoxy-phenyl)-chromen-4-one 

Relevant articles and documents

Synthesis, biological evaluation, and NMR studies of 3-fluorinated derivatives of 3′,4′,5′-trihydroxyflavone and 3′,4′,5′-trimethoxyflavone

Flavones are valuable scaffolds in medicinal chemistry, especially as they display activity as antioxidants and neuroprotective agents. The need to incorporate a fluorine atom on flavones has driven much of the recent synthetic work in this area. We now r

Design, synthesis and biological evaluation of 2-Phenyl-4H-chromen-4-one derivatives as polyfunctional compounds against Alzheimer’s disease

Polyfunctional compounds comprise a novel class of therapeutic agents for the treatment of multi-factorial diseases. A series of 2-Phenyl-4H-chromen-4-one and its derivatives (5a–n) were designed, synthesized, and evaluated for their poly-functionality against acetylcholinestrase (AChE) and advanced glycation end products (AGEs) formation inhibitors against Alzheimer’s disease (AD). The screening results showed that most of them exhibited a significant ability to inhibit AChE AGEs formation with additional radical scavenging activity. Especially, 5m, 5b, and 5j displayed the greatest ability to inhibit AChE (IC50 = 8.0, 8.2, and 11.8 nM, respectively) and AGEs formation (IC50 = 55, 79, and 54 μM, respectively) with good antioxidant activity. Molecular docking studies explored the detailed interaction pattern with active, peripheral, and mid-gorge sites of AChE. These compounds, exhibiting such multiple pharmacological activities, can be further taken a lead for the development of potent drugs for the treatment of Alzheimer’s disease.

Synthesis and anti-trypanosoma cruzi activity of diaryldiazepines

Chagas disease is a so-called "neglected disease" and endemic to Latin America. Nifurtimox and benznidazole are drugs that have considerable efficacy in the treatment of the acute phase of the disease but cause many significant side effects. Furthermore, in the Chronic Phase its efficiency is reduced and their therapeutic effectiveness is dependent on the type of T. cruzi strain. For this reason, the present work aims to drive basic research towards the discovery of new chemical entities to treat Chagas disease. Differently substituted 5,7-diaryl-2,3-dihydro-1,4-diazepines were synthesized by cyclocondensation of substituted flavones with ethylenediamine and tested as anti-Trypanosoma cruzi candidates. Epimastigotes of the Y strain from T. cruzi were used in this study and the number of parasites was determined in a Neubauer chamber. The most potent diaryldiazepine that reduced epimastigote proliferation exhibited an IC50 value of 0.25 μM, which is significantly more active than benznidazole.