69705-14-2

Basic information

• Product Name: biotin tosylate
• Synonyms: biotin tosylate;(3aS,4S,6aR)-Tetrahydro-4-[5-[[(4-methylphenyl)sulfonyl]oxy]pentyl]-1H-thieno[3,4-d]imidazol-2(3H)-one
• CAS NO: 69705-14-2
• Molecular Weight: 384.521
• Mol File: 69705-14-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: biotin tosylate(CAS DataBase Reference)
• NIST Chemistry Reference: biotin tosylate(69705-14-2)
• EPA Substance Registry System: biotin tosylate(69705-14-2)

Safety Data

• Hazardous Substances Data: 69705-14-2(Hazardous Substances Data)

Upstream product

• 608-16-2 biotin methyl ester 
• 58-85-5 biotin 
• 87573-52-2 5-[(3aS,4S,6aR)-2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl]-pentanoic acid ethyl ester 
• 98-59-9 p-toluenesulfonyl chloride 
• 53906-36-8 1H-thieno<3,4-d>imidazol-2(3H)-one, tetrahydro-4-(5-hydroxypentyl)-, <3aS-(3aα,4β,6aα)>- 

Downstream Products

• 1379655-82-9 homobiotin tosylate 
• 304439-23-4 (3aS,4S,6aR)-4-(5-bromo-pentyl)tetrahydrothieno[3,4-d]imidazol-2-one 

Relevant articles and documents

Avidin/Biotin Bioinspired Platform for Dual in Vivo 18F-PET/NIRF Molecular Imaging

The complementary nature of positron emission tomography (PET) and near-infrared fluorescence (NIRF) imaging makes the development of innovative multimodal PET/NIRF probes a very exciting prospect. Herein, the bioinspired design of novel platform exploiting the strength and specificity of interactions between radioactive and fluorescent biotin derivatives and an avidin core is reported. The combination of an original [18F]fluoropyridinylated-biotin derivative and commercially available fluorescent biotin derivatives (Atto-425 and Atto-680) is investigated. The in vivo distribution of such a customized platform is also reported, for the first time, in healthy rodent using PET and ex vivo fluorescence imaging.

Chemoselective triazole-phosphonamidate conjugates suitable for photorelease

Herein, we describe a new method for the conjugation of azide-containing target compounds that can be readily released as amines by irradiation with near UV light. This concept is based on a two-step protocol employing the chemoselective CuAAC and Staudinger-phosphonite reactions to deliver photo-cleavable phosphonamidate conjugates in high yields starting from 2-nitrobenzyl substituted phosphonites.

A photocleavable rapamycin conjugate for spatiotemporal control of small GTPase activity

We developed a novel method to spatiotemporally control the activity of signaling molecules. A newly synthesized photocaged rapamycin derivative induced rapid dimerization of FKBP (FK-506 binding protein) and FRB (FKBP-rapamycin binding protein) upon UV i