6971-10-4

Basic information

• Product Name: methyl (E)-3-carbamoylprop-2-enoate
• Synonyms: methyl (E)-3-carbamoylprop-2-enoate
• CAS NO: 6971-10-4
• Molecular Formula: C₅H₇NO₃
• Molecular Weight: 0
• Mol File: 6971-10-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 291.9°C at 760 mmHg
• Flash Point: 178.3°C
• Appearance: /
• Density: 1.184g/cm³
• Vapor Pressure: 0.0019mmHg at 25°C
• Refractive Index: 1.473
• CAS DataBase Reference: methyl (E)-3-carbamoylprop-2-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (E)-3-carbamoylprop-2-enoate(6971-10-4)
• EPA Substance Registry System: methyl (E)-3-carbamoylprop-2-enoate(6971-10-4)

Safety Data

• Hazardous Substances Data: 6971-10-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C5H7NO3/c1-9-5(8)3-2-4(6)7/h2-3H,1H3,(H2,6,7)/b3-2+

Upstream product

• 67-56-1 methanol 
• 2987-87-3 fumaramic acid 
• 4674-96-8 Flavensomycinylsaeure 
• 17081-97-9 methyl (E)-4-chloro-4-oxo-2-butenoate 
• 141805-68-7 N-(3-Chloro-4-hydroxyphenylacetyl)fumarate 
• 2756-87-8 methyl hydrogen fumarate 

Downstream Products

• 627-64-5 fumaramide 
• 925-56-4 (E)-methyl 3-cyanoacrylate 

Relevant articles and documents

Determination of the Absolute Configurations of Microtermolides A and B

Absolute configurations of the three consecutive chiral centers in the cyclic depsipeptide microtermolide A have been tentatively assigned as 2?R, 3?R, and 4?R. However, on the basis of a structural comparison with vinylamycin, another depsipeptide with a unique 4-amino-2,4-pentadienolate structure, the chiral centers could also be assigned as 2?R, 3?R, and 4?S. Here, the first total synthesis of microtermolide A is reported and the configurations of the three consecutive chiral centers were confirmed to be 2?R, 3?R, and 4?S. A similar approach was used to determine the analogous centers in microtermolide B as 2?R, 3?R, and 4?S.

THERAPEUTIC COMPOUNDS AND METHODS OF USE

The invention relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

Biologically Active Metabolites of Fungi, I.-Isolation, Synthesis, and Biological Activity of Coniothyriomycin as well as Bioassay of Analogous Open-Chain Imides

The mixed open-chain imide N-(3-chloro-4-hydroxyphenylacetyl)fumarate (1), named coniothyriomycin, was isolated as a metabolite of the fungus Coniothyrium.The natural product 1 and the analoguos imides 13-15 and 22-24 have been synthesized by base-catalyzed condensation of the imidates 12a-f with acid chlorides 6a-c or the mixed anhydride 21.The compounds 1 and 13-15 were shown to posess remarkable fungicidal and herbicidal activities in short-termed tests. Key Words: Fungal metabolites / Imides, open-chain / Fungicidal activity / Coniothriomycin