6971-44-4

Basic information

• Product Name: METHYLPYRIDIN-4-YLMETHYLAMINE
• Synonyms: ASINEX-REAG BAS 09614979;METHYLPYRIDIN-4-YLMETHYLAMINE;N-METHYL-N-(4-PYRIDINYLMETHYL)AMINE;N-methylpyridine-4-methylamine;n-methyl-n-(4-pyridylmethyl)amine;N-METHYL-N-(PYRIDIN-4-YLMETHYL)AMINE;N-Methyl-4-pyridylmethylamine;N-Methyl-N-(4-pyridylmethyl)amine ,97%
• CAS NO: 6971-44-4
• Molecular Formula: C₇H₁₀N₂
• Molecular Weight: 122.17
• EINECS: 230-198-6
• Product Categories: Amines and Anilines;Heterocycles;API intermediates;Aminomethyl's;Pyridines
• Mol File: 6971-44-4.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 86 °C
• Flash Point: 75℃
• Appearance: /
• Density: 0.982
• Vapor Pressure: 0.332mmHg at 25°C
• Refractive Index: 1.515
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.27±0.10(Predicted)
• CAS DataBase Reference: METHYLPYRIDIN-4-YLMETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYLPYRIDIN-4-YLMETHYLAMINE(6971-44-4)
• EPA Substance Registry System: METHYLPYRIDIN-4-YLMETHYLAMINE(6971-44-4)

Safety Data

• Hazard Codes: Xi
• Statements: 22-34
• Safety Statements: 23-26-36/37/39-45
• RIDADR: 2922
• HazardClass: IRRITANT
• Hazardous Substances Data: 6971-44-4(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

InChI:InChI=1/C7H10N2/c1-8-6-7-2-4-9-5-3-7/h2-5,8H,6H2,1H3

Upstream product

• 1822-51-1 4-picolylchloride hydrochloride 
• 74-89-5 methylamine 
• 872-85-5 pyridine-4-carbaldehyde 
• 593-51-1 methylamine hydrochloride 
• 42182-68-3 N-(4-Pyridinylmethyl)-N'-methylformamide 
• 16273-55-5 N-(pyridin-4-ylmethylene)methanamine 
• 3731-53-1 4-(aminomethyl)pyridine 
• 56625-05-9 N-(4-picolyl)formamide 

Downstream Products

• 128739-02-6 N-(4-picolyl)-2-(methylamino)-1-phenyl-1-ethanol 
• 147238-88-8 Carbonic acid benzyl ester 2,6-dimethoxy-4-{(5R,5aR,8aR,9S)-9-[2-(methyl-pyridin-4-ylmethyl-amino)-ethyl]-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl}-phenyl ester 
• 165558-98-5 5-methyl>amino>-8-nitronaphthalene-1-carbonitrile 
• 128739-18-4 2-(Methyl-pyridin-4-ylmethyl-amino)-1-phenyl-ethanol; compound with (E)-but-2-enedioic acid 
• 152121-22-7 4-methoxy-N-methyl-N-(4-picolyl)benzamide 
• 1123309-80-7 N-((3R,5R)-5-{[(1,3-benzothiazol-2-ylmethyl)(methyl)amino]methyl}-1-cyano-3-pyrrolidinyl)-2,5-dibromobenzenesulfonamide 
• 1416267-51-0 4-(4-fluorophenyl)-5-mercapto-N-methyl-N-(pyridin-4-ylmethyl)-4H-1,2,4-triazole-3-carboxamide 
• 1416267-49-6 2-(2-((4-fluorophenyl)carbamothioyl)hydrazinyl)-N-methyl-2-oxo-N-(pyridin-4-yl-methyl)acetamide 
• 1421847-11-1 2-{2-[1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}-N-methyl-N-(pyridin-4-ylmethyl)acetamide 

Relevant articles and documents

Base-Promoted Tandem Synthesis of 2-Azaaryl Tetrahydroquinolines

A novel method to synthesize 2-azaaryl tetrahydroquinolines by the base-promoted tandem reaction of azaaryl methyl amines and styrene derivatives is reported (over 30 examples, yields up to 95%). Mechanistic probe experiments demonstrate that the deprotonation of the benzylic C-H bond and the addition to the styrene vinyl group proceeds via the SNAr mechanism.

The interplay of secondary Hg...S, Hg...N and Hg...π bonding interactions in supramolecular structures of phenylmercury(ii) dithiocarbamates

Three new phenylmercury(ii) and one mercury(ii) dithiocarbamate complexes viz. PhHg S2CN(PyCH2)Bz (1), PhHg S 2CN(PyCH2)CH3 (2), PhHg S2CN(Bz) CH3 (3), and [Hg (NCS2(PyCH2)Bz)2] (4) (Py = pyridine; Bz = benzyl) have been synthesized and characterized by elemental analyses, IR, electronic absorption, 1H and 13C NMR spectroscopy. The crystal structures of 1, 2 and 3 showed a linear S-Hg-C core at the centre of the molecule, in which the metal atom is bound to the sulfur atom of the dithiocarbamate ligand and a carbon atom of the aromatic ring. In contrast the crystal structure of 4 showed a linear S-Hg-S core at the Hg(ii) centre of the molecule. Weak intermolecular Hg...N (Py) interactions link molecules into a linear chain in the case of 1, whereas chains of dimers are formed in 2 through intermolecular Hg...N (Py) and Hg...S interactions. 3 forms a conventional face-to-edge dimeric structure through intermolecular Hg...S secondary bonding and 4 forms a linear chain of dimers through face-to-face Hg...S secondary bonding. In order to elucidate the nature of these secondary bonding interactions and the electronic absorption spectra of the complexes, ab initio quantum chemical calculations at the MP2 level and density functional theory calculations were carried out for 1-3. Complexes 1 and 2 exhibited photoluminescent properties in the solid state as well as in the solution phase. Studies indicate that Hg...S interactions decrease and Hg...N interactions increase the chances of photoluminescence in the solid phase The Royal Society of Chemistry 2011.

KETOLIDE DERIVATIVES AS ANTIBACTERIAL AGENTS

The present invention provides ketolide derivatives, which can be used as antibacterial agents. In particular, compounds described herein can be used for treating or preventing conditions caused by or contributed to by Gram-positive, Gram-negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus or Enterobactericeae. Also provided are processes for preparing siuch ketolide derivatives, pharmaceutical compositions thereof, and methods of treating bacterial infections.