697284-64-3

Basic information

• Product Name: (R)-{3-methyl-1-[4-(3-oxo-morpholin-4-yl)-phenylcarbamoyl]-butyl}-carbamic acid tert-butyl ester
• CAS NO: 697284-64-3
• Molecular Weight: 405.494
• Mol File: 697284-64-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-{3-methyl-1-[4-(3-oxo-morpholin-4-yl)-phenylcarbamoyl]-butyl}-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-{3-methyl-1-[4-(3-oxo-morpholin-4-yl)-phenylcarbamoyl]-butyl}-carbamic acid tert-butyl ester(697284-64-3)
• EPA Substance Registry System: (R)-{3-methyl-1-[4-(3-oxo-morpholin-4-yl)-phenylcarbamoyl]-butyl}-carbamic acid tert-butyl ester(697284-64-3)

Safety Data

• Hazardous Substances Data: 697284-64-3(Hazardous Substances Data)

Upstream product

• 100-01-6 4-nitro-aniline 
• 811450-82-5 4-(2-(2-chloroethoxy)acetamido)1-nitrobenzene 
• 446292-04-2 4-(4-nitrophenyl)-3-morpholinone 
• 16937-99-8 N-Boc-D-Leu 
• 438056-69-0 4-(4-aminophenyl)morpholin-3-one 

Downstream Products

• 769119-47-3 (R)-2-Amino-4-methyl-pentanoic acid [4-(3-oxo-morpholin-4-yl)-phenyl]-amide 
• 697284-65-4 (R)-2-amino-4-methyl-pentanoic acid [4-(3-oxo-morpholin-4-yl)-phenyl]-amide hydrochloride 

Relevant articles and documents

Chlorothiophenecarboxamides as P1 surrogates of inhibitors of blood coagulation factor Xa

Neutral chlorothiophenecarboxamides bearing an amino acid and a substituted aniline were synthesized and investigated for their factor Xa inhibitory activity in vitro. From selected 2-methylphenyl morpholinones the solution properties were determined. The most soluble and active compounds were then investigated in different animal species to compare the pharmacokinetic parameters. This led to a potent, water soluble and orally bioavailable candidate for further development: EMD 495235.