697299-82-4 Usage
Description
N-De[2-(Methylsulfonyl)ethyl] Lapatinib is a reactive metabolite of Lapatinib (L175800), a medication primarily used for the treatment of breast cancer. It is formed through the metabolism of Lapatinib by the enzyme P450 3A4, resulting in the formation of Oand N-dealkylated metabolites. This specific metabolite is associated with various drug toxicities, which may impact the safety and efficacy of Lapatinib treatment.
Uses
Used in Pharmaceutical Industry:
N-De[2-(Methylsulfonyl)ethyl] Lapatinib is used as a research compound for understanding the metabolic pathways and toxicities associated with Lapatinib. This knowledge is crucial for the development of safer and more effective cancer treatments, as well as for the improvement of drug delivery systems and the management of drug-related side effects.
Used in Drug Metabolism Studies:
N-De[2-(Methylsulfonyl)ethyl] Lapatinib serves as an important tool in drug metabolism studies, helping researchers to identify and characterize the metabolic products of Lapatinib. This information is vital for assessing the safety profile of the drug and for optimizing its pharmacokinetic properties.
Used in Toxicity Assessment:
As a metabolite associated with drug toxicities, N-De[2-(Methylsulfonyl)ethyl] Lapatinib is used in toxicity assessment studies to evaluate the potential risks and side effects of Lapatinib treatment. This helps in the development of strategies to mitigate these toxicities and improve patient outcomes.
Used in Drug Interaction Studies:
N-De[2-(Methylsulfonyl)ethyl] Lapatinib is also used in drug interaction studies to investigate the potential for drug-drug interactions involving Lapatinib. Understanding these interactions is essential for the safe and effective use of Lapatinib in combination with other medications.
Check Digit Verification of cas no
The CAS Registry Mumber 697299-82-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,9,7,2,9 and 9 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 697299-82:
(8*6)+(7*9)+(6*7)+(5*2)+(4*9)+(3*9)+(2*8)+(1*2)=244
244 % 10 = 4
So 697299-82-4 is a valid CAS Registry Number.
697299-82-4Relevant articles and documents
Cyanoguanidines and cyanoamidines as ErbB2 and EGFR inhibitors
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Page/Page column 9, (2008/06/13)
Cyanoguanidine quinazoline and cyanoamidine quinazolamine derivatives that are useful in the treatment of hyperproliferative diseases are disclosed. Methods of treating hyperproliferative diseases in mammals are also disclosed.
Heterocyclic compounds
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, (2008/06/13)
The present invention relates to substituted heteroaromatic compounds, methods for their preparation, pharmaceutical compositions containing them and their use in medicine. Specifically, the invention relates to quinazoline derivatives useful in treating disorders mediated by protein tyrosine kinase activity, in particular erbB-2 and/or EGFR activity.
